Phenotypes associated with this allele

• Allele Symbol: Hsd11b2^tm1.1Mzz
• Allele Name: targeted mutation 1.1, Ming-Zhi Zhang
• Allele ID: MGI:5547496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apc^Min/Apc^+ Hsd11b2^tm1.1Mzz/Hsd11b2^tm1.1Mzz Tg(Vil1-cre)997Gum/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:5547498

Genotype
MGI:5547498

cn1

• Allelic Composition: Apc^Min/Apc⁺; Hsd11b2^tm1.1Mzz/Hsd11b2^tm1.1Mzz; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:205456 )

• fewer total intestinal adenoma at 20 weeks with prevented initiation of polyp formation compared with Apc^Min heterozygotes

decreased tumor growth/size ( J:205456 )

• reduced proliferation and increased apoptosis compared with tumors from Apc^Min heterozygotes

homeostasis/metabolism

abnormal corticosterone level ( J:205456 )

• 10-fold higher corticosterone (active glucocorticoid) levels in the intestine compared with Apc^Min heterozygotes

• 11-keto-corticosterone (inactive glucocorticoid) levels is lower in the intestine compared with Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:205456 )

• fewer total intestinal adenoma at 20 weeks with prevented initiation of polyp formation compared with Apc^Min heterozygotes