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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnip1tm1.2Ama
targeted mutation 1.2, Averil Ma
MGI:5547505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:5547520
cn2
 		Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:5547518


Genotype
MGI:5547520
cn1
Allelic
Composition		 Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1tm1.2Ama mutation (0 available); any Tnip1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:205446 )
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz hematopoietic stem cells used in transplantation experiments, hematopoietic stem cells do not alter susceptibility to IMQ-induced psoriasis

immune system
immune system phenotype ( J:205446 )
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz mice, mice exhibit normal spleen mass, myeloid cell numbers and activated T lymphocyte




Genotype
MGI:5547518
cn2
Allelic
Composition		 Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1tm1.2Ama mutation (0 available); any Tnip1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:205446 )
• by 3 to 4 months with accumulation of myeloid and memory T cells
abnormal leukocyte morphology ( J:205446 )
• increased CD11b+Gr1+ myeloid cells
increased memory T cell number ( J:205446 )
• CD4+ and CD8+ memory T cells
enlarged lymph nodes ( J:205446 )
• by 3 to 4 months with accumulation of myeloid and memory T cells
increased interleukin-12 secretion ( J:205446 )
• from bone marrow-derived dendritic cells stimulated with LPS
increased interleukin-23 secretion ( J:205446 )
• from bone marrow-derived dendritic cells stimulated with LPS
increased interleukin-6 secretion ( J:205446 )
• from bone marrow-derived dendritic cells stimulated with LPS
increased tumor necrosis factor secretion ( J:205446 )
• from bone marrow-derived dendritic cells stimulated with LPS

hematopoietic system
enlarged spleen ( J:205446 )
• by 3 to 4 months with accumulation of myeloid and memory T cells
abnormal leukocyte morphology ( J:205446 )
• increased CD11b+Gr1+ myeloid cells
increased memory T cell number ( J:205446 )
• CD4+ and CD8+ memory T cells
abnormal hematopoietic stem cell physiology ( J:205446 )
• hematopoietic stem cells transplanted into irradiated recipient mice exhibit increased susceptibility to IMQ-induced psoriasis compared with control cells

growth/size/body
enlarged spleen ( J:205446 )
• by 3 to 4 months with accumulation of myeloid and memory T cells




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory