Phenotypes associated with this allele

• Allele Symbol: Lat^tm9Mal
• Allele Name: targeted mutation 9, Bernard Malissen
• Allele ID: MGI:5547536
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lat^tm9Mal/Lat^tm9Mal	involves: C57BL/6	MGI:5547580
cx2	Lat^tm9Mal/Lat^tm9Mal Carmil2^bas/Carmil2^bas	involves: C3HeB/FeJ * C57BL/6	MGI:5547582

Genotype
MGI:5547580

hm1

• Allelic Composition: Lat^tm9Mal/Lat^tm9Mal
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:205441 )

• authors state that mice exhibit the same phenotype as Lat^tm1Mal

abnormal lymphopoiesis ( J:205441 )

• lymphoproliferative disease

abnormal B cell number ( J:205441 )

• abnormal activated B cells

increased T-helper 2 cell number ( J:205441 )

abnormal immune system physiology ( J:205441 )

• authors state that mice exhibit the same phenotype as Lat^tm1Mal

hematopoietic system

abnormal lymphopoiesis ( J:205441 )

• lymphoproliferative disease

abnormal B cell number ( J:205441 )

• abnormal activated B cells

increased T-helper 2 cell number ( J:205441 )

Genotype
MGI:5547582

cx2

• Allelic Composition: Lat^tm9Mal/Lat^tm9Mal; Carmil2^bas/Carmil2^bas
• Genetic Background: involves: C3HeB/FeJ * C57BL/6

immune system

immune system phenotype ( J:205441 )

N • unlike Lat^tm8Mal homozygotes, mice exhibit normal numbers of CD4+ T cells and Th2 effector cells