Analysis Tools
mortality/aging
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• mice die within 10 weeks
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integument
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• hair loss begins during the first hair cycle
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sparse hair
(
J:202499
)
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• less dense at P6
|
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• fewer follicles develop and degenerate to cyst-like structures
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• degenerate to cyst-like structures
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• irritated, flaky and thin skin with exposed blood vessels
• Munro's microabscesses all over the skin
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flaky skin
(
J:202499
)
reddish skin
(
J:202499
)
|
• red-nose phenotype at P6
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scaly skin
(
J:202499
)
|
• hyperproliferative epidermis with increased proportion of proliferating basal cells but fewer number of proliferating cells in the bulb
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• at P6, but not in neonates
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• with fluid retention
• neutrophil infiltration in the dermis at P16 that is not reduced by antibiotic treatment
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immune system
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• reduced at P90, but not P4 or P28
|
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• relative weight at P21 and P65, but not P4
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• at P40, but not P4
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• T cell maturation is shifted away from alpha/beta T cells in the thymus at P40
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• at P40 in the thymus
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• at P40 in the thymus
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• increased mast cell number in the skin
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• neutrophil infiltration in the dermis at P16 that is not reduced by antibiotic treatment
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• the ratio of CD4 to CD8 T cells is decreased at P40 in the thymus, lymph node and blood
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• reduced CD3+ T cells in the thymus
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• age-dependent decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin
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• in the skin
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• dendritic epidermal T cell survival is impaired
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• of dendritic epidermal T cell
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• with fluid retention
• neutrophil infiltration in the dermis at P16 that is not reduced by antibiotic treatment
|
vision/eye
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• swollen eye
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hearing/vestibular/ear
craniofacial
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• red-nose phenotype at P6
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respiratory system
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• red-nose phenotype at P6
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adipose tissue
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• mice exhibit lack of fat tissue sustainment
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growth/size/body
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• red-nose phenotype at P6
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homeostasis/metabolism
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• in adult mice
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• at P6, but not in neonates
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hematopoietic system
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• reduced at P90, but not P4 or P28
|
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• relative weight at P21 and P65, but not P4
|
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• at P40, but not P4
|
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• T cell maturation is shifted away from alpha/beta T cells in the thymus at P40
|
|
• at P40 in the thymus
|
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• increased mast cell number in the skin
|
|
• neutrophil infiltration in the dermis at P16 that is not reduced by antibiotic treatment
|
|
• the ratio of CD4 to CD8 T cells is decreased at P40 in the thymus, lymph node and blood
|
|
• reduced CD3+ T cells in the thymus
|
|
• at P40 in the thymus
|
|
• age-dependent decrease in gamma-delta TCR+ T cells (dendritic epidermal T cells) in the skin
|
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• in the skin
|
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• dendritic epidermal T cell survival is impaired
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• of dendritic epidermal T cell
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cellular
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• of dendritic epidermal T cell
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endocrine/exocrine glands
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• reduced at P90, but not P4 or P28
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• relative weight at P21 and P65, but not P4
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• at P40, but not P4
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