Phenotypes associated with this allele

• Allele Symbol: Adamts6^b2b2187.1Clo
• Allele Name: Bench to Bassinet Program (B2B/CVDC), mutation 2187, subline 1, Cecilia Lo
• Allele ID: MGI:5547743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts6^b2b2187.1Clo/Adamts6^b2b2187.1Clo	C57BL/6J-Adamts6^b2b2187.1Clo	MGI:5549973

Genotype
MGI:5549973

hm1

• Allelic Composition: Adamts6^b2b2187.1Clo/Adamts6^b2b2187.1Clo
• Genetic Background: C57BL/6J-Adamts6^b2b2187.1Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 2187-004-NC has a hypoplastic aorta and pulmonary stenosis as well as DORV and biventricular hypertrophy that was confirmed by EFIC imaging

cardiovascular system

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

double outlet right ventricle ( J:175213 )

double outlet right ventricle with atrioventricular septal defect ( J:175213 )

overriding aortic valve ( J:175213 )

atrioventricular septal defect ( J:175213 )

ventricular septal defect ( J:175213 )

perimembraneous ventricular septal defect ( J:175213 )

muscular ventricular septal defect ( J:175213 )

craniofacial

cleft palate ( J:175213 )

short snout ( J:175213 )

digestive/alimentary system

cleft palate ( J:175213 )

hematopoietic system

thymus hypoplasia ( J:175213 )

homeostasis/metabolism

hydrops fetalis ( J:175213 )

immune system

thymus hypoplasia ( J:175213 )

limbs/digits/tail

abnormal hindlimb morphology ( J:175213 )

• abnormal flexure of the hindlimbs

skeleton

abnormal vertebrae morphology ( J:175213 )

• midline fusion defect of the sternal vertebra

endocrine/exocrine glands

thymus hypoplasia ( J:175213 )

growth/size/body

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

cleft palate ( J:175213 )

short snout ( J:175213 )

muscle

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )