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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkmtm1.1Mgvh
targeted mutation 1.1, Matthew G Vander Heiden
MGI:5547750
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pkmtm1.1Mgvh/Pkmtm1.1Mgvh involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:5547936
cn2
 		Brca1tm2Cxd/Brca1tm2Cxd
Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:5547937


Genotype
MGI:5547936
hm1
Allelic
Composition		 Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkmtm1.1Mgvh mutation (2 available); any Pkm mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:205213 )
• mice are healthy and have no overt phenotype




Genotype
MGI:5547937
cn2
Allelic
Composition		 Brca1tm2Cxd/Brca1tm2Cxd
Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (114 available)
Pkmtm1.1Mgvh mutation (2 available); any Pkm mutation (80 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:205213 )
• accelerated tumor associated mortality relative to control mice

neoplasm
increased mammary gland tumor incidence ( J:205213 )
• mice develop breast tumors similar to control mice
increased liver tumor incidence ( J:205213 )
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice
increased metastatic potential ( J:205213 )
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:205213 )
• mice develop breast tumors similar to control mice

integument
increased mammary gland tumor incidence ( J:205213 )
• mice develop breast tumors similar to control mice

liver/biliary system
increased liver tumor incidence ( J:205213 )
• liver metastases observed in 3/5 mice as compared to 0/7 relative to control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory