All Phenotypes Myod1<tm1.1(cre/ERT,TVA)Gcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myod1^{tm1.1(cre/ERT,TVA)Gcg}
targeted mutation 1.1, Gerard C Grosveld
MGI:5547828

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Myod1^{tm1.1(cre/ERT,TVA)Gcg}/Myod1⁺ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5547939

Allelic Composition	Kras^tm4Tyj/Kras⁺ Myod1^{tm1.1(cre/ERT,TVA)Gcg}/Myod1⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Myod1^{tm1.1(cre/ERT,TVA)Gcg} mutation (1 available); any Myod1 mutation (23 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:205518 )

• when mice older than 6 weeks are given systemic tamoxifen treatment by intraperitoneal delivery, mice develop multiple tumors at clinically relevant sites with a median tumor free survival of 153 days (longer latency than Pax7^CE mutants

increased sarcoma incidence ( J:205518 )

• tamoxifen treated mice develop sarcomas that are exclusively undifferentiated pleomorphic sarcomas (UPS), myogenic or nonmyogenic in type

• tumors can appear in the body wall, the extremities, or the head and neck region

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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