Phenotypes associated with this allele

• Allele Symbol: Nacc1^tm1.1Jlwa
• Allele Name: targeted mutation 1.1, Jianlong Wang
• Allele ID: MGI:5547984
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nacc1^tm1.1Jlwa/Nacc1^tm1.1Jlwa	involves: 129S1/Sv * C57BL/6	MGI:5547985
ht2	Nacc1^tm1.1Jlwa/Nacc1^+	involves: 129S1/Sv * C57BL/6	MGI:5547986

Genotype
MGI:5547985

hm1

• Allelic Composition: Nacc1^tm1.1Jlwa/Nacc1^tm1.1Jlwa
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:203277 )

• fewer than expected mice are present at weaning

reproductive system

reduced female fertility ( J:203277 )

reduced male fertility ( J:203277 )

skeleton

decreased rib number ( J:203277 )

• in some mice with the T12 phenotype

abnormal vertebrae morphology ( J:203277 )

• mice exhibit a T13/L5 (jn most mice) or T12/L6 (in some mice) configuration compared with T13/L6 (in most) or T13/L5 (in few) wild-type mice

abnormal thoracic vertebrae morphology ( J:203277 )

• T10, T11 and T12 in some mice exhibit high incidence of fissures affecting the dorsal surface

thoracic vertebral transformation ( J:203277 )

• T13 to a lumbar vertebrae

abnormal lumbar vertebrae morphology ( J:203277 )

• missing sixth lumbar vertebrae

decreased presacral vertebrae number ( J:203277 )

• in some E15 and adult mice

sacral vertebral fusion ( J:203277 )

• fusion of all sacral vertebrae

abnormal chondrocyte physiology ( J:203277 )

• reduced migration

• however, proliferation is normal

Genotype
MGI:5547986

ht2

• Allelic Composition: Nacc1^tm1.1Jlwa/Nacc1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

skeleton

abnormal vertebrae morphology ( J:203277 )

• some mice exhibit an intermediate phenotype with T13/L5 configuration compared with wild-type mice

lumbar vertebral transformation ( J:203277 )

• some mice exhibit asymmetrical partial transformation of L6 into a sacral identity

decreased presacral vertebrae number ( J:203277 )

• in some E15 and adult mice

abnormal chondrocyte physiology ( J:203277 )

• reduced migration

• however, proliferation is normal