Phenotypes associated with this allele

• Allele Symbol: Adgrf5^tm1Shiro
• Allele Name: targeted mutation 1, Shigehisa Hirose
• Allele ID: MGI:5547987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrf5^tm1Shiro/Adgrf5^tm1Shiro	B6.Cg-Adgrf5^tm1Shiro	MGI:5547988

Genotype
MGI:5547988

hm1

• Allelic Composition: Adgrf5^tm1Shiro/Adgrf5^tm1Shiro
• Genetic Background: B6.Cg-Adgrf5^tm1Shiro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased lung weight ( J:204701 )

• 1.3 times

abnormal alveolar macrophage morphology ( J:204701 )

• increased number and enlargement of alveolar macrophage with abundant cytoplasmic vesicles

abnormal pulmonary alveolus morphology ( J:204701 )

• reduced number and increased volume of alveoli

increased type II pneumocyte number ( J:204701 )

emphysema ( J:204701 )

increased surfactant secretion ( J:204701 )

• in the bronchoalveolar lavage fluid

• however, surfactant composition is normal

immune system

increased macrophage cell number ( J:204701 )

• progressive increase in the bronchoalveolar lavage fluid beginning around 3 weeks of age

• increased number and enlargement of alveolar macrophage

abnormal alveolar macrophage morphology ( J:204701 )

• increased number and enlargement of alveolar macrophage with abundant cytoplasmic vesicles

hematopoietic system

increased macrophage cell number ( J:204701 )

• progressive increase in the bronchoalveolar lavage fluid beginning around 3 weeks of age

• increased number and enlargement of alveolar macrophage

abnormal alveolar macrophage morphology ( J:204701 )

• increased number and enlargement of alveolar macrophage with abundant cytoplasmic vesicles

growth/size/body

increased lung weight ( J:204701 )

• 1.3 times