Phenotypes associated with this allele

• Allele Symbol: Samd4^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5547989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Samd4^m1Btlr/Samd4^m1Btlr	C57BL/6J-Samd4^m1Btlr	MGI:5567841

Genotype
MGI:5567841

hm1

• Allelic Composition: Samd4^m1Btlr/Samd4^m1Btlr
• Genetic Background: C57BL/6J-Samd4^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:208616 )

• mice begin to die at 3 months

reproductive system

female infertility ( J:208616 )

♀

male infertility ( J:208616 )

♂

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:208616 )

• in mice fed a high fat diet

increased circulating LDL cholesterol level ( J:208616 )

• in mice fed a high fat diet

decreased circulating cholesterol level ( J:208616 )

• in mice fed a high fat diet

decreased circulating HDL cholesterol level ( J:208616 )

• in mice fed a high fat diet

increased carbon dioxide production ( J:208616 )

increased oxygen consumption ( J:208616 )

abnormal glucose homeostasis ( J:208616 )

• delayed glucose clearance during a glucose tolerance test

decreased insulin secretion ( J:208616 )

• in fasted mice

decreased circulating glucose level ( J:208616 )

• in fasted mice

decreased circulating insulin level ( J:208616 )

• in fasted mice

decreased skeletal muscle glycogen level ( J:208616 )

increased insulin sensitivity ( J:208616 )

• moderately

adipose tissue

adipose tissue phenotype ( J:208616 )

N • brown adipose tissue is normal

increased subcutaneous adipose tissue amount ( J:208616 )

decreased total body fat amount ( J:208616 )

• visceral fat

• however, transgenic expression of the gene rescues fat volume

abnormal white fat cell morphology ( J:208616 )

• abnormal fat droplet accumulation in the cytoplasm

decreased white fat cell size ( J:208616 )

decreased gonadal fat pad weight ( J:208616 )

• decreased epigonadal white adipose tissue

decreased inguinal fat pad weight ( J:208616 )

muscle

abnormal muscle fiber morphology ( J:208616 )

• focal myofibers with irregular shapes and heterogenous sizes

abnormal skeletal muscle morphology ( J:208616 )

• reduced size of slow-twitch (type I) fibers

decreased skeletal muscle glycogen level ( J:208616 )

centrally nucleated skeletal muscle fibers ( J:208616 )

muscle hypoplasia ( J:208616 )

• decreased muscle volume

• however, transgenic expression of the gene rescues muscle volume

myopathy ( J:208616 )

• widely scattered focal myopathy in gastrocnemius, soleus, extensor digitorum longus, and tibialis anterior muscles

growth/size/body

abnormal body composition ( J:208616 )

• lean body

decreased body mass index ( J:208616 )

• in mice fed standard chow

decreased body weight ( J:208616 )

• in mice fed standard chow

• however, transgenic expression of the gene increased body weight

decreased body length ( J:208616 )

• in mice fed standard chow

decreased susceptibility to diet-induced obesity ( J:208616 )

• in mice fed a high fat diet

behavior/neurological

decreased locomotor activity ( J:208616 )

endocrine/exocrine glands

decreased insulin secretion ( J:208616 )

• in fasted mice

integument

increased subcutaneous adipose tissue amount ( J:208616 )

liver/biliary system

hepatic steatosis ( J:208616 )

• 1 in 4 mice fed a high fat diet

skeleton

skeleton phenotype ( J:208616 )

N • mice exhibit normal bone mineral density and bone mineral content

kyphosis ( J:208616 )

• thoracic