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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhoatm1Csab
targeted mutation 1, Charles S Abrams
MGI:5548162
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhoatm1Csab/Rhoatm1Csab Not Specified MGI:5548166
cn2
 		Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam
Rhoatm1Csab/Rhoatm1Csab
Tg(ITGA2B)3Mako/0
Tg(Pf4-icre)Q3Rsko/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:5548168
cn3
 		Rhoatm1Csab/Rhoatm1Csab
Tg(Pf4-icre)Q3Rsko/0 		involves: C57BL/6 MGI:5548167


Genotype
MGI:5548166
hm1
Allelic
Composition		 Rhoatm1Csab/Rhoatm1Csab
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoatm1Csab mutation (0 available); any Rhoa mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:204459 )
• mice are grossly normal




Genotype
MGI:5548168
cn2
Allelic
Composition		 Itga2btm1(GFP/cre)Emam/Itga2btm1(GFP/cre)Emam
Rhoatm1Csab/Rhoatm1Csab
Tg(ITGA2B)3Mako/0
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2btm1(GFP/cre)Emam mutation (0 available); any Itga2b mutation (45 available)
Rhoatm1Csab mutation (0 available); any Rhoa mutation (73 available)
Tg(ITGA2B)3Mako mutation (0 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte morphology ( J:204459 )
• cultured megakaryocytes derived from fetal liver E13.5 exhibit altered ploidy distribution (modal ploidy 16N compared with normal 2N) and larger size compared with control cells
• megakaryocytes are stiffer than in control cells
abnormal megakaryocyte differentiation ( J:204459 )
• in vivo platelet production is impaired

cellular
abnormal megakaryocyte differentiation ( J:204459 )
• in vivo platelet production is impaired




Genotype
MGI:5548167
cn3
Allelic
Composition		 Rhoatm1Csab/Rhoatm1Csab
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoatm1Csab mutation (0 available); any Rhoa mutation (73 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:204459 )
• macrothrombocytopenia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory