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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfatm2Cbet
targeted mutation 2, Christer Betsholtz
MGI:5548172
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdgfatm2Cbet/Pdgfatm2Cbet involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5548176
cx2
 		Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy 		B6.129-Pdgfctm1Nagy Pdgfatm2Cbet MGI:5548180
cx3
 		Pdgfatm1Cbet/Pdgfatm2Cbet
Pdgfratm11(EGFP)Sor/Pdgfra+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5548177
cx4
 		Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5548178


Genotype
MGI:5548176
hm1
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205009 )
N
• unlike Pdgfatm1Cbet homozygotes, mice survive to adulthood

respiratory system
respiratory system phenotype ( J:205009 )
N
• mice exhibit normal lung morphology




Genotype
MGI:5548180
cx2
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic
Background		 B6.129-Pdgfctm1Nagy Pdgfatm2Cbet
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (20 available)
Pdgfctm1Nagy mutation (0 available); any Pdgfc mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:205009 )
• in all mice, but heterogeneity in severity
spina bifida occulta ( J:205009 )
• in 2 of 5 mice

nervous system
spina bifida ( J:205009 )
• in all mice, but heterogeneity in severity
spina bifida occulta ( J:205009 )
• in 2 of 5 mice

skeleton
spina bifida occulta ( J:205009 )
• in 2 of 5 mice




Genotype
MGI:5548177
cx3
Allelic
Composition		 Pdgfatm1Cbet/Pdgfatm2Cbet
Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm1Cbet mutation (0 available); any Pdgfa mutation (20 available)
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (20 available)
Pdgfratm11(EGFP)Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung morphology ( J:205009 )
• progressive dilated distal airway
emphysema ( J:205009 )
• at 3 months

digestive/alimentary system
digestive/alimentary phenotype ( J:205009 )
N
• mice exhibit normal gastrointestinal tract

renal/urinary system
renal/urinary system phenotype ( J:205009 )
N
• mice exhibit normal kidneys

skeleton
skeleton phenotype ( J:205009 )
N
• mice exhibit normal skeleton




Genotype
MGI:5548178
cx4
Allelic
Composition		 Pdgfatm2Cbet/Pdgfatm2Cbet
Pdgfctm1Nagy/Pdgfctm1Nagy
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfatm2Cbet mutation (1 available); any Pdgfa mutation (20 available)
Pdgfctm1Nagy mutation (0 available); any Pdgfc mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:205009 )
• in all mice
spina bifida occulta ( J:205009 )
• in some mice

digestive/alimentary system
abnormal small intestine morphology ( J:205009 )
• reduced thickness of the submucosal mesenchyme in the upper small intestine
decreased small intestinal villus number ( J:205009 )
• reduced number of villi in the upper small intestine

growth/size/body
decreased body size ( J:205009 )

skeleton
spina bifida occulta ( J:205009 )
• in some mice
kyphosis ( J:205009 )
• severe kyphosis of the thoracic spine in 3 of 11 mice

embryo
spina bifida ( J:205009 )
• in all mice
spina bifida occulta ( J:205009 )
• in some mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory