Phenotypes associated with this allele

• Allele Symbol: Ap2a2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap2a2^tm1b(EUCOMM)Wtsi/Ap2a2^tm1b(EUCOMM)Wtsi	C57BL/6N-Ap2a2^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5756705
ht2	Ap2a2^tm1b(EUCOMM)Wtsi/Ap2a2^+	C57BL/6N-Ap2a2^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5756704

Genotype
MGI:5756705

hm1

• Allelic Composition: Ap2a2^{tm1b(EUCOMM)Wtsi}/Ap2a2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Ap2a2^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0719_1_C02

Data Sources

IMPC Data for Ap2a2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent pinna reflex ( J:211773 )

♀

IMPC - WTSI

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♀

IMPC - WTSI

increased circulating cholesterol level ( J:211773 )

♀

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

♀

IMPC - WTSI

increased circulating iron level ( J:211773 )

♀

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

♀

IMPC - WTSI

Genotype
MGI:5756704

ht2

• Allelic Composition: Ap2a2^{tm1b(EUCOMM)Wtsi}/Ap2a2⁺
• Genetic Background: C57BL/6N-Ap2a2^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0719_1_C02

Data Sources

IMPC Data for Ap2a2

homeostasis/metabolism

increased circulating free fatty acids level ( J:211773 )

♀

IMPC - WTSI