Phenotypes associated with this allele

• Allele Symbol: Wars1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548346
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wars1^tm1b(EUCOMM)Hmgu/Wars1^tm1b(EUCOMM)Hmgu	C57BL/6N-Wars^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757884
ht2	Wars1^tm1b(EUCOMM)Hmgu/Wars1^+	C57BL/6N-Wars^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757883

Genotype
MGI:5757884

hm1

• Allelic Composition: Wars1^{tm1b(EUCOMM)Hmgu}/Wars1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Wars^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0563_6_G06

Data Sources

IMPC Data for Wars1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757883

ht2

• Allelic Composition: Wars1^{tm1b(EUCOMM)Hmgu}/Wars1⁺
• Genetic Background: C57BL/6N-Wars^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0563_6_G06

Data Sources

IMPC Data for Wars1

behavior/neurological

impaired righting response ( J:211773 )

IMPC - HMGU

abnormal gait ( J:211773 )

IMPC - HMGU

cardiovascular system

dilated heart left ventricle ( J:211773 )

IMPC - HMGU

decreased cardiac muscle contractility ( J:211773 )

♀

IMPC - HMGU

decreased heart rate ( J:211773 )

♀

IMPC - HMGU

growth/size/body

polycystic kidney ( J:211773 )

♀

IMPC - HMGU

enlarged liver ( J:211773 )

♂

IMPC - HMGU

increased liver weight ( J:211773 )

♂

IMPC - HMGU

hematopoietic system

increased erythrocyte cell number ( J:211773 )

♀

IMPC - HMGU

decreased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - HMGU

decreased mean corpuscular volume ( J:211773 )

IMPC - HMGU

increased red blood cell distribution width ( J:211773 )

♀

IMPC - HMGU

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - HMGU

decreased circulating unsaturated transferrin level ( J:211773 )

♂

IMPC - HMGU

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - HMGU

enlarged liver ( J:211773 )

♂

IMPC - HMGU

increased liver weight ( J:211773 )

♂

IMPC - HMGU

muscle

decreased cardiac muscle contractility ( J:211773 )

♀

IMPC - HMGU

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - HMGU

polycystic kidney ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

♀

IMPC - HMGU