Phenotypes associated with this allele

• Allele Symbol: Wnt10a^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5548381
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt10a^tm1.1(KOMP)Vlcg/Wnt10a^tm1.1(KOMP)Vlcg	C57BL/6N-Wnt10a^tm1.1(KOMP)Vlcg/Ucd	MGI:5631687
hm2	Wnt10a^tm1.1(KOMP)Vlcg/Wnt10a^tm1.1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5816727

Genotype
MGI:5631687

hm1

• Allelic Composition: Wnt10a^{tm1.1(KOMP)Vlcg}/Wnt10a^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Wnt10a^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 14810A-D3

Data Sources

IMPC Data for Wnt10a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - UCD

integument

abnormal coat/ hair morphology ( J:211773 )

IMPC - UCD

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - UCD

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - UCD

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - UCD

skeleton

short tibia ( J:211773 )

♀

IMPC - UCD

increased bone mineral content ( J:211773 )

IMPC - UCD

Genotype
MGI:5816727

hm2

• Allelic Composition: Wnt10a^{tm1.1(KOMP)Vlcg}/Wnt10a^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 14810A-D3

craniofacial

dental pulp stones ( J:223527 )

• dental pulp calcification

taurodontia ( J:223527 )

• taurodontic molar root morphology of all three molars with elongated root trunks and low or absent furcation in the first and second molar

• vertically elongated pulp chamber with very little root canals

• external root resorption

abnormal incisor morphology ( J:223527 )

• V-shaped density defect in the lingual side of the apical end of incisors

• single gap lingually or two gaps depending upon whether a single or double wedge deficiency has formed

abnormal molar crown morphology ( J:223527 )

• reduced occlusal table, especially first molars, with decreased mesio-distal dimensions and convergent cusp pattern

• reduced mesio-distal dimension one first molar with a rounded-square shape

abnormal molar cusp morphology ( J:223527 )

• cusp 4 is absent from the first molar

• three buccal casups (B1-3) and the first lingual cusp (L1) are fused

• smaller L2 and L3 lingual cusps

• deep U-shaped groove surrounding the second lingual cusp (L2) with a blackening carious appearance in one mouse

• molar 2 lacks cusp 4

• irregular concavities of molars

• however, molar 3 has normal crown morphology and cusp pattern

small molars ( J:223527 )

• small second and third molar

• reduced tooth volume

supernumerary molars ( J:223527 )

• small fourth mandibular molar with a single cusp and thin root in one mouse with residual extra sockets in other mice indicating loss of fourth molars

abnormal dentin morphology ( J:223527 )

• reduced volume

abnormal dentin mineralization ( J:223527 )

• delayed or defective dentin mineralization at the lingual surface of mandibular incisor

growth/size/body

dental pulp stones ( J:223527 )

• dental pulp calcification

taurodontia ( J:223527 )

• taurodontic molar root morphology of all three molars with elongated root trunks and low or absent furcation in the first and second molar

• vertically elongated pulp chamber with very little root canals

• external root resorption

abnormal incisor morphology ( J:223527 )

• V-shaped density defect in the lingual side of the apical end of incisors

• single gap lingually or two gaps depending upon whether a single or double wedge deficiency has formed

abnormal molar crown morphology ( J:223527 )

• reduced mesio-distal dimension one first molar with a rounded-square shape

• reduced occlusal table, especially first molars, with decreased mesio-distal dimensions and convergent cusp pattern

abnormal molar cusp morphology ( J:223527 )

• cusp 4 is absent from the first molar

• three buccal casups (B1-3) and the first lingual cusp (L1) are fused

• smaller L2 and L3 lingual cusps

• deep U-shaped groove surrounding the second lingual cusp (L2) with a blackening carious appearance in one mouse

• molar 2 lacks cusp 4

• irregular concavities of molars

• however, molar 3 has normal crown morphology and cusp pattern

small molars ( J:223527 )

• small second and third molar

• reduced tooth volume

supernumerary molars ( J:223527 )

• small fourth mandibular molar with a single cusp and thin root in one mouse with residual extra sockets in other mice indicating loss of fourth molars

abnormal dentin morphology ( J:223527 )

• reduced volume

abnormal dentin mineralization ( J:223527 )

• delayed or defective dentin mineralization at the lingual surface of mandibular incisor

skeleton

dental pulp stones ( J:223527 )

• dental pulp calcification

taurodontia ( J:223527 )

• taurodontic molar root morphology of all three molars with elongated root trunks and low or absent furcation in the first and second molar

• vertically elongated pulp chamber with very little root canals

• external root resorption

abnormal incisor morphology ( J:223527 )

• V-shaped density defect in the lingual side of the apical end of incisors

• single gap lingually or two gaps depending upon whether a single or double wedge deficiency has formed

abnormal molar crown morphology ( J:223527 )

• reduced mesio-distal dimension one first molar with a rounded-square shape

• reduced occlusal table, especially first molars, with decreased mesio-distal dimensions and convergent cusp pattern

abnormal molar cusp morphology ( J:223527 )

• cusp 4 is absent from the first molar

• three buccal casups (B1-3) and the first lingual cusp (L1) are fused

• smaller L2 and L3 lingual cusps

• deep U-shaped groove surrounding the second lingual cusp (L2) with a blackening carious appearance in one mouse

• molar 2 lacks cusp 4

• irregular concavities of molars

• however, molar 3 has normal crown morphology and cusp pattern

small molars ( J:223527 )

• small second and third molar

• reduced tooth volume

supernumerary molars ( J:223527 )

• small fourth mandibular molar with a single cusp and thin root in one mouse with residual extra sockets in other mice indicating loss of fourth molars

abnormal dentin morphology ( J:223527 )

• reduced volume

abnormal dentin mineralization ( J:223527 )

• delayed or defective dentin mineralization at the lingual surface of mandibular incisor

abnormal tooth root resorption ( J:223527 )

• external root resorption