All Phenotypes Tulp3<tm1b(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tulp3^{tm1b(EUCOMM)Hmgu}
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5548429

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3^{tm1b(EUCOMM)Hmgu}	C57BL/6N-Tulp3^{tm1b(EUCOMM)Hmgu}/H	MGI:5757836
hm2	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3^{tm1b(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N * FVB/NJ	MGI:6392265
ht3	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3⁺	C57BL/6N-Tulp3^{tm1b(EUCOMM)Hmgu}/H	MGI:5757835
ht4	Tulp3^m1Kflj/Tulp3^{tm1b(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6J * C57BL/6N * FVB/NJ	MGI:6392264

Allelic Composition	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3^{tm1b(EUCOMM)Hmgu}
Genetic Background	C57BL/6N-Tulp3^{tm1b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0508_5_B01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp3^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Tulp3 mutation (54 available)

Data Sources

IMPC Data for Tulp3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Allelic Composition	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3^{tm1b(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp3^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Tulp3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality prior to heart atrial septation ( J:284006 )

• mutants die around E14.5

craniofacial

abnormal craniofacial morphology ( J:284006 )

• craniofacial defects at E14.5

embryo

open neural tube ( J:284006 )

• open neural tube at E14.5

homeostasis/metabolism

edema ( J:284006 )

• edema is seen at E14.5

limbs/digits/tail

polydactyly ( J:284006 )

nervous system

open neural tube ( J:284006 )

• open neural tube at E14.5

skeleton

abnormal skeleton development ( J:284006 )

• severe skeletal defects

Allelic Composition	Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3⁺
Genetic Background	C57BL/6N-Tulp3^{tm1b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0508_5_B01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp3^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Tulp3 mutation (54 available)

Data Sources

IMPC Data for Tulp3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - HAR

decreased fasting circulating glucose level ( J:211773 )

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

impaired glucose tolerance ( J:211773 )

IMPC - HAR

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - HAR

Allelic Composition	Tulp3^m1Kflj/Tulp3^{tm1b(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6N * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp3^m1Kflj mutation (0 available); any Tulp3 mutation (54 available)
Tulp3^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Tulp3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:284006 )

• kidney cysts are seen at E18.5

growth/size/body

kidney cyst ( J:284006 )

• kidney cysts are seen at E18.5

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