All Phenotypes Ap4e1<tm1b(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ap4e1^{tm1b(KOMP)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5548434

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay	MGI:5756710
hm2	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ccpcz	MGI:6408243
hm3	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg	MGI:5756709
hm4	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J	MGI:5756711
hm5	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6325110
hm6	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl	MGI:5756713
hm7	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd	MGI:5756712
hm8	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Wtsi	MGI:5756708

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac output ( J:211773 )

IMPC - BCM

decreased heart rate ( J:211773 )

IMPC - BCM

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

immune system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ccpcz
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:211773 )

IMPC - CCP-IMG

abnormal freezing behavior ( J:211773 )

IMPC - CCP-IMG

hyperactivity ( J:211773 )

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

IMPC - CCP-IMG

small testis ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

increased erythrocyte cell number ( J:211773 )

IMPC - CCP-IMG

increased hemoglobin content ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - CCP-IMG

decreased circulating chloride level ( J:211773 )

IMPC - CCP-IMG

abnormal cholesterol homeostasis ( J:211773 )

IMPC - CCP-IMG

reproductive system

abnormal testis morphology ( J:211773 )

IMPC - CCP-IMG

small testis ( J:211773 )

IMPC - CCP-IMG

respiratory system

abnormal inspiratory capacity ( J:211773 )

IMPC - CCP-IMG

increased lung compliance ( J:211773 )

IMPC - CCP-IMG

skeleton

abnormal vertebrae morphology ( J:211773 )

IMPC - CCP-IMG

abnormal vertebral arch morphology ( J:211773 )

IMPC - CCP-IMG

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased exploration in new environment ( J:211773 )

IMPC - HMGU

increased startle reflex ( J:211773 )

IMPC - HMGU

hyperactivity ( J:211773 )

IMPC - HMGU

cardiovascular system

increased cardiac muscle contractility ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating amylase level ( J:211773 )

IMPC - HMGU

impaired glucose tolerance ( J:211773 )

IMPC - HMGU

muscle

increased cardiac muscle contractility ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

decreased total retina thickness ( J:211773 )

IMPC - HMGU

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - JAX

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - JAX

decreased thigmotaxis ( J:211773 )

IMPC - JAX

decreased vertical activity ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

abnormal sleep behavior ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - UCD

behavior/neurological

increased startle reflex ( J:211773 )

IMPC - UCD

decreased grip strength ( J:211773 )

IMPC - UCD

hyperactivity ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

growth/size/body

increased lean body mass ( J:211773 )

IMPC - UCD

increased kidney weight ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - UCD

decreased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - UCD

increased red blood cell distribution width ( J:211773 )

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

increased kidney weight ( J:211773 )

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

IMPC - UCD

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - ICS

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - ICS

vision/eye

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

behavior/neurological

impaired contextual conditioning behavior ( J:211773 )

IMPC - TCP

abnormal freezing behavior ( J:211773 )

IMPC - TCP

increased startle reflex ( J:211773 )

IMPC - TCP

hyperactivity ( J:211773 )

IMPC - TCP

cardiovascular system

cardiovascular system phenotype ( J:211773 )

IMPC - TCP

increased heart weight ( J:211773 )

IMPC - TCP

abnormal sinus arrhythmia ( J:211773 )

IMPC - TCP

decreased heart rate variability ( J:211773 )

IMPC - TCP

growth/size/body

increased heart weight ( J:211773 )

IMPC - TCP

increased lean body mass ( J:211773 )

IMPC - TCP

immune system

enlarged lymph nodes ( J:211773 )

IMPC - TCP

skeleton

increased bone mineral content ( J:211773 )

IMPC - TCP

Allelic Composition	Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0025_5_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4e1^{tm1b(KOMP)Wtsi} mutation (4 available); any Ap4e1 mutation (59 available)

Data Sources

IMPC Data for Ap4e1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

increased startle reflex ( J:211773 )

IMPC - RBRC

limb grasping ( J:211773 )

IMPC - HAR

increased grip strength ( J:211773 )

IMPC - WTSI

hyperactivity ( J:211773 )

IMPC - RBRC

growth/size/body

increased kidney weight ( J:211773 )

IMPC - HAR

hematopoietic system

increased hematocrit ( J:211773 )

IMPC - RBRC

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - RBRC

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

increased circulating creatine kinase level ( J:211773 )

IMPC - RBRC

decreased respiratory quotient ( J:211773 )

IMPC - RBRC

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - RBRC

renal/urinary system

increased kidney weight ( J:211773 )

IMPC - HAR

skeleton

increased bone mineral content ( J:211773 )

IMPC - WTSI

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