Phenotypes associated with this allele

• Allele Symbol: Bag3^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548479
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bag3^tm1b(EUCOMM)Hmgu/Bag3^tm1b(EUCOMM)Hmgu	C57BL/6N-Bag3^tm1b(EUCOMM)Hmgu/H	MGI:5756780
hm2	Bag3^tm1b(EUCOMM)Hmgu/Bag3^tm1b(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6154623
ht3	Bag3^tm1b(EUCOMM)Hmgu/Bag3^+	C57BL/6N-Bag3^tm1b(EUCOMM)Hmgu/H	MGI:5756779

Genotype
MGI:5756780

hm1

• Allelic Composition: Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Bag3^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0556_7_B06

Data Sources

IMPC Data for Bag3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6154623

hm2

• Allelic Composition: Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0556_7_B06

Significant growth retardation in Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu} mice

mortality/aging

preweaning lethality, complete penetrance ( J:246352 )

• early lethality at 3-4 weeks of age

growth/size/body

decreased body weight ( J:246352 )

postnatal growth retardation ( J:246352 )

• impaired postnatal growth

Genotype
MGI:5756779

ht3

• Allelic Composition: Bag3^{tm1b(EUCOMM)Hmgu}/Bag3⁺
• Genetic Background: C57BL/6N-Bag3^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0556_7_B06

Data Sources

IMPC Data for Bag3

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

♀

IMPC - HAR