All Phenotypes Rnf10<tm1b(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnf10^{tm1b(KOMP)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5548492

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay	MGI:5757639
hm2	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H	MGI:5757635
hm3	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics	MGI:5757634
hm4	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg	MGI:5757640
hm5	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J	MGI:5757637
hm6	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6325175
hm7	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc	MGI:5757638
hm8	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd	MGI:5757641
hm9	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi	MGI:5757636
ht10	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg	MGI:5757633
ht11	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6480574
ht12	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd	MGI:5757632

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - BCM

hyperactivity ( J:211773 )

IMPC - BCM

increased vertical activity ( J:211773 )

IMPC - BCM

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

immune system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - BCM

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:211773 )

IMPC - HAR

limb grasping ( J:211773 )

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

hyperactivity ( J:211773 )

IMPC - HAR

hematopoietic system

decreased hemoglobin content ( J:211773 )

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

decreased circulating total protein level ( J:211773 )

IMPC - HAR

immune system

increased large unstained cell number ( J:211773 )

IMPC - HAR

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - HAR

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - ICS

decreased exploration in new environment ( J:211773 )

IMPC - ICS

increased anxiety-related response ( J:211773 )

IMPC - ICS

abnormal freezing behavior ( J:211773 )

IMPC - ICS

decreased grip strength ( J:211773 )

IMPC - ICS

increased vertical activity ( J:211773 )

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

cardiovascular system

shortened QT interval ( J:211773 )

IMPC - ICS

shortened ST segment ( J:211773 )

IMPC - ICS

growth/size/body

decreased body length ( J:211773 )

IMPC - ICS

hematopoietic system

decreased lymphocyte cell number ( J:211773 )

IMPC - ICS

increased monocyte cell number ( J:211773 )

IMPC - ICS

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

IMPC - ICS

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - ICS

decreased circulating serum albumin level ( J:211773 )

IMPC - ICS

improved glucose tolerance ( J:211773 )

IMPC - ICS

immune system

decreased lymphocyte cell number ( J:211773 )

IMPC - ICS

increased monocyte cell number ( J:211773 )

IMPC - ICS

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - ICS

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - ICS

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased vertical activity ( J:211773 )

IMPC - HMGU

decreased locomotor activity ( J:211773 )

IMPC - HMGU

hyperactivity ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

IMPC - HMGU

decreased circulating serum albumin level ( J:211773 )

IMPC - HMGU

decreased circulating total protein level ( J:211773 )

IMPC - HMGU

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HMGU

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased thigmotaxis ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

convulsive seizures ( J:211773 )

IMPC - JAX

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - JAX

decreased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX

decreased fasting circulating glucose level ( J:211773 )

IMPC - JAX

increased circulating sodium level ( J:211773 )

IMPC - JAX

nervous system

convulsive seizures ( J:211773 )

IMPC - JAX

decreased prepulse inhibition ( J:211773 )

IMPC - JAX

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hemoglobin content ( J:211773 )

IMPC - RBRC

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - RBRC

decreased mean corpuscular volume ( J:211773 )

IMPC - RBRC

skeleton

increased bone mineral content ( J:211773 )

IMPC - RBRC

decreased bone mineral density ( J:211773 )

IMPC - RBRC

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - TCP

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

absent pinna reflex ( J:211773 )

IMPC - WTSI

decreased grip strength ( J:211773 )

IMPC - WTSI

growth/size/body

increased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

skeleton

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

increased bone mineral content ( J:211773 )

IMPC - WTSI

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - HMGU

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

IMPC - UCD

Allelic Composition	Rnf10^{tm1b(KOMP)Wtsi}/Rnf10⁺
Genetic Background	C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0025_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf10^{tm1b(KOMP)Wtsi} mutation (2 available); any Rnf10 mutation (53 available)

Data Sources

IMPC Data for Rnf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

cardiovascular system

enlarged heart ( J:211773 )

IMPC - TCP

increased heart weight ( J:211773 )

IMPC - TCP

growth/size/body

enlarged heart ( J:211773 )

IMPC - TCP

increased heart weight ( J:211773 )

IMPC - TCP

homeostasis/metabolism

decreased circulating triglyceride level ( J:211773 )

IMPC - TCP

decreased circulating serum albumin level ( J:211773 )

IMPC - TCP

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