Phenotypes associated with this allele

• Allele Symbol: Timm50^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548523
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timm50^tm1b(EUCOMM)Wtsi/Timm50^tm1b(EUCOMM)Wtsi	C57BL/6N-Timm50^tm1b(EUCOMM)Wtsi/Ics	MGI:5757811
ht2	Timm50^tm1b(EUCOMM)Wtsi/Timm50^+	C57BL/6N-Timm50^tm1b(EUCOMM)Wtsi/Ics	MGI:5757810

Genotype
MGI:5757811

hm1

• Allelic Composition: Timm50^{tm1b(EUCOMM)Wtsi}/Timm50^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Timm50^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0144_2_D04

Data Sources

IMPC Data for Timm50

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - ICS

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757810

ht2

• Allelic Composition: Timm50^{tm1b(EUCOMM)Wtsi}/Timm50⁺
• Genetic Background: C57BL/6N-Timm50^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0144_2_D04

Data Sources

IMPC Data for Timm50

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - ICS

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - ICS

decreased body length ( J:211773 )

♂

IMPC - ICS

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - ICS

skeleton

decreased bone mineral content ( J:211773 )

♂

IMPC - ICS

increased bone mineral density ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina outer nuclear layer morphology ( J:211773 )

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS