Phenotypes associated with this allele

• Allele Symbol: Yae1d1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548529
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Yae1d1^tm1b(EUCOMM)Hmgu/Yae1d1^tm1b(EUCOMM)Hmgu	C57BL/6N-Yae1d1^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263894
ht2	Yae1d1^tm1b(EUCOMM)Hmgu/Yae1d1^+	C57BL/6N-Yae1d1^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263893

Genotype
MGI:6263894

hm1

• Allelic Composition: Yae1d1^{tm1b(EUCOMM)Hmgu}/Yae1d1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Yae1d1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0704_7_A01

Data Sources

IMPC Data for Yae1d1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263893

ht2

• Allelic Composition: Yae1d1^{tm1b(EUCOMM)Hmgu}/Yae1d1⁺
• Genetic Background: C57BL/6N-Yae1d1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0704_7_A01

Data Sources

IMPC Data for Yae1d1

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - HMGU

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HMGU

increased circulating lipase level ( J:211773 )

♀

IMPC - HMGU

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

♀

IMPC - HMGU