Phenotypes associated with this allele

• Allele Symbol: Dis3^{tm1e.1(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1e.1, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548623
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dis3^tm1e.1(EUCOMM)Hmgu/Dis3^tm1e.1(EUCOMM)Hmgu	C57BL/6N-Dis3^tm1e.1(EUCOMM)Hmgu/Ieg	MGI:5756995
ht2	Dis3^tm1e.1(EUCOMM)Hmgu/Dis3^+	C57BL/6N-Dis3^tm1e.1(EUCOMM)Hmgu/Ieg	MGI:5756994

Genotype
MGI:5756995

hm1

• Allelic Composition: Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3^{tm1e.1(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0659_5_E08

Data Sources

IMPC Data for Dis3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5756994

ht2

• Allelic Composition: Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3⁺
• Genetic Background: C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0659_5_E08

Data Sources

IMPC Data for Dis3

behavior/neurological

increased startle reflex ( J:211773 )

♂

IMPC - HMGU

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal retina morphology ( J:211773 )

♀

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

abnormal vitreous body morphology ( J:211773 )

♂

IMPC - HMGU