|
Allele Symbol Allele Name Allele ID |
Fam151btm1b(EUCOMM)Hmgu targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH MGI:5548636 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
IMPC - HAR
|
|
|
IMPC - HAR
|
|
IMPC - HAR
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age p21 and 11 weeks
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age p21 and 11 weeks
|
|
• GFAP-positive staining starting at around age P15 but normal layer thickness
• reduced layer thickness by age P21
|
|
• little or no scotopic and photopic response to light flashes at age P21
• normal scotopic and photopic response under standard light intensity at age P15
|
|
• little or no scotopic and photopic response to light flashes at age P21
• normal scotopic and photopic response under standard light intensity at age P15
|
|
• patchy pigmentation at age p21 and 11 and 15 weeks
|
| N |
• normal retinal pigment epithelium (RPE) morphology
• normal nerve patterning in embryos age E16.5
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age p21 and 11 weeks
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age p21 and 11 weeks
|
|
• GFAP-positive staining starting at around age P15 but normal layer thickness
• reduced layer thickness by age P21
|
|
• little or no scotopic and photopic response to light flashes at age P21
• normal scotopic and photopic response under standard light intensity at age P15
|
|
• little or no scotopic and photopic response to light flashes at age P21
• normal scotopic and photopic response under standard light intensity at age P15
|
|
• patchy pigmentation at age p21 and 11 and 15 weeks
|
|
• significantly reduced scotopic a-wave when stimulated with high intensity light source at age P15
• little or no scotopic and photopic response to light flashes at age P21
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
|
|
• reduced layer thickness at age P21
|
|
• patchy pigmentation at age P21
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
|
|
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
|
|
• reduced layer thickness at age P21
|
|
• patchy pigmentation at age P21
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 06/12/2024 MGI 6.13 |
|
|
|
||
Analysis Tools