Phenotypes associated with this allele

• Allele Symbol: Hsf2bp^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548644
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf2bp^tm1b(EUCOMM)Hmgu/Hsf2bp^tm1b(EUCOMM)Hmgu	C57BL/6N-Hsf2bp^tm1b(EUCOMM)Hmgu/Ieg	MGI:5767688
hm2	Hsf2bp^tm1b(EUCOMM)Hmgu/Hsf2bp^tm1b(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6456829

Genotype
MGI:5767688

hm1

• Allelic Composition: Hsf2bp^{tm1b(EUCOMM)Hmgu}/Hsf2bp^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Hsf2bp^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0520_6_B03

Data Sources

IMPC Data for Hsf2bp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small testis ( J:211773 )

♂

IMPC - HMGU

immune system

enlarged lymph nodes ( J:211773 )

♀

IMPC - HMGU

reproductive system

small testis ( J:211773 )

♂

IMPC - HMGU

Genotype
MGI:6456829

hm2

• Allelic Composition: Hsf2bp^{tm1b(EUCOMM)Hmgu}/Hsf2bp^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

reproductive system

male infertility ( J:292036 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:292036 )

♂ • unrepaired DSBs persist until late prophase I in spermatocytes

♂ • (near) absence of BRCA2, RAD1 BRME1, and DMC1 punctuate foci at DSBs in spermatocytes

♂ • increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes

♂ • normal presence of RPA2 punctuate foci at DSBs in spermatocytes

cellular

abnormal double-strand DNA break repair ( J:292036 )

♂ • unrepaired DSBs persist until late prophase I in spermatocytes

♂ • (near) absence of BRCA2, RAD1 BRME1, and DMC1 punctuate foci at DSBs in spermatocytes

♂ • increased intensity of SPATA22 punctuate foci at DSBs in spermatocytes

♂ • normal presence of RPA2 punctuate foci at DSBs in spermatocytes