Phenotypes associated with this allele

• Allele Symbol: Pbrm1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548674
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbrm1^tm1b(EUCOMM)Wtsi/Pbrm1^tm1b(EUCOMM)Wtsi	C57BL/6N-Pbrm1^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263108
ht2	Pbrm1^tm1b(EUCOMM)Wtsi/Pbrm1^+	C57BL/6N-Pbrm1^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263107

Genotype
MGI:6263108

hm1

• Allelic Composition: Pbrm1^{tm1b(EUCOMM)Wtsi}/Pbrm1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pbrm1^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0089_3_C01

Data Sources

IMPC Data for Pbrm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263107

ht2

• Allelic Composition: Pbrm1^{tm1b(EUCOMM)Wtsi}/Pbrm1⁺
• Genetic Background: C57BL/6N-Pbrm1^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0089_3_C01

Data Sources

IMPC Data for Pbrm1

behavior/neurological

abnormal gait ( J:211773 )

♀

IMPC - HMGU

hematopoietic system

increased mean platelet volume ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - HMGU

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - HMGU

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - HMGU