Phenotypes associated with this allele

• Allele Symbol: Memo1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548676
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Memo1^tm1b(EUCOMM)Wtsi/Memo1^tm1b(EUCOMM)Wtsi	C57BL/6N-Memo1^tm1b(EUCOMM)Wtsi/Bay	MGI:5757357
hm2	Memo1^tm1b(EUCOMM)Wtsi/Memo1^tm1b(EUCOMM)Wtsi	involves: Black Swiss * C57BL/6 * FVB/N	MGI:6400481
ht3	Memo1^tm1b(EUCOMM)Wtsi/Memo1^+	C57BL/6N-Memo1^tm1b(EUCOMM)Wtsi/Bay	MGI:5767723

Genotype
MGI:5757357

hm1

• Allelic Composition: Memo1^{tm1b(EUCOMM)Wtsi}/Memo1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Memo1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0785_3_A06

Data Sources

IMPC Data for Memo1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal pericardium morphology ( J:211773 )

IMPC - BCM

hemorrhage ( J:211773 )

IMPC - BCM

embryo

abnormal embryo size ( J:211773 )

IMPC - BCM

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - BCM

homeostasis/metabolism

edema ( J:211773 )

IMPC - BCM

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6400481

hm2

• Allelic Composition: Memo1^{tm1b(EUCOMM)Wtsi}/Memo1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: Black Swiss * C57BL/6 * FVB/N

mortality/aging

preweaning lethality, complete penetrance ( J:233609 )

• fail to thrive after birth

craniofacial

domed cranium ( J:233609 )

cleft secondary palate ( J:233609 )

abnormal nasal bridge morphology ( J:233609 )

• misshapen

digestive/alimentary system

cleft secondary palate ( J:233609 )

growth/size/body

cleft secondary palate ( J:233609 )

abnormal nasal bridge morphology ( J:233609 )

• misshapen

respiratory system

abnormal nasal bridge morphology ( J:233609 )

• misshapen

skeleton

domed cranium ( J:233609 )

Genotype
MGI:5767723

ht3

• Allelic Composition: Memo1^{tm1b(EUCOMM)Wtsi}/Memo1⁺
• Genetic Background: C57BL/6N-Memo1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0785_3_A06

Data Sources

IMPC Data for Memo1

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

cardiovascular system

thick ventricular wall ( J:211773 )

♀

IMPC - BCM