Phenotypes associated with this allele

• Allele Symbol: Coq6^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548683
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coq6^tm1b(EUCOMM)Hmgu/Coq6^tm1b(EUCOMM)Hmgu	C57BL/6N-Coq6^tm1b(EUCOMM)Hmgu/Ics	MGI:5630989
hm2	Coq6^tm1b(EUCOMM)Hmgu/Coq6^tm1b(EUCOMM)Hmgu	B6N(Cg)-Coq6^tm1b(EUCOMM)Hmgu/J	MGI:5756906
ht3	Coq6^tm1b(EUCOMM)Hmgu/Coq6^+	C57BL/6N-Coq6^tm1b(EUCOMM)Hmgu/Ics	MGI:5630988
ht4	Coq6^tm1b(EUCOMM)Hmgu/Coq6^+	B6N(Cg)-Coq6^tm1b(EUCOMM)Hmgu/J	MGI:5767609

Genotype
MGI:5630989

hm1

• Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Coq6^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0535_5_A07

Data Sources

IMPC Data for Coq6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5756906

hm2

• Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6^{tm1b(EUCOMM)Hmgu}
• Genetic Background: B6N(Cg)-Coq6^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0535_5_H05

Data Sources

IMPC Data for Coq6

embryo

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

♀

IMPC - JAX

abnormal tail bud morphology ( J:211773 )

IMPC - JAX

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

♀

IMPC - JAX

limbs/digits/tail

abnormal tail bud morphology ( J:211773 )

IMPC - JAX

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

nervous system

abnormal forebrain development ( J:211773 )

IMPC - JAX

Genotype
MGI:5630988

ht3

• Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6⁺
• Genetic Background: C57BL/6N-Coq6^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0535_5_A07

Data Sources

IMPC Data for Coq6

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal cornea morphology ( J:211773 )

IMPC - ICS

abnormal vitreous body morphology ( J:211773 )

♀

IMPC - ICS

persistence of hyaloid vascular system ( J:211773 )

♂

IMPC - ICS

Genotype
MGI:5767609

ht4

• Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6⁺
• Genetic Background: B6N(Cg)-Coq6^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0535_5_H05

Data Sources

IMPC Data for Coq6

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

♂

IMPC - JAX