Phenotypes associated with this allele

• Allele Symbol: Agl^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548686
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agl^tm1b(EUCOMM)Wtsi/Agl^tm1b(EUCOMM)Wtsi	C57BL/6N-Agl^tm1b(EUCOMM)Wtsi/H	MGI:5756667
ht2	Agl^tm1b(EUCOMM)Wtsi/Agl^+	C57BL/6N-Agl^tm1b(EUCOMM)Wtsi/H	MGI:5756666

Genotype
MGI:5756667

hm1

• Allelic Composition: Agl^{tm1b(EUCOMM)Wtsi}/Agl^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Agl^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0371_2_E12

Data Sources

IMPC Data for Agl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♀

IMPC - HAR

behavior/neurological

abnormal gait ( J:211773 )

♂

IMPC - HAR

cardiovascular system

increased heart weight ( J:211773 )

♀

IMPC - HAR

growth/size/body

increased heart weight ( J:211773 )

♀

IMPC - HAR

increased lean body mass ( J:211773 )

♀

IMPC - HAR

increased kidney weight ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - HAR

increased fasting circulating glucose level ( J:211773 )

♀

IMPC - HAR

decreased circulating glucose level ( J:211773 )

♀

IMPC - HAR

increased circulating cholesterol level ( J:211773 )

♀

IMPC - HAR

increased circulating iron level ( J:211773 )

♀

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HAR

increased circulating amylase level ( J:211773 )

♀

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - HAR

increased circulating creatine kinase level ( J:211773 )

♀

IMPC - HAR

impaired glucose tolerance ( J:211773 )

♀

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

renal/urinary system

increased kidney weight ( J:211773 )

♀

IMPC - HAR

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - HAR

decreased bone mineral density ( J:211773 )

♀

IMPC - HAR

vision/eye

cataract ( J:211773 )

IMPC - HAR

Genotype
MGI:5756666

ht2

• Allelic Composition: Agl^{tm1b(EUCOMM)Wtsi}/Agl⁺
• Genetic Background: C57BL/6N-Agl^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0371_2_E12

Data Sources

IMPC Data for Agl

behavior/neurological

tremors ( J:211773 )

IMPC - HAR