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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Odad3tm1b(EUCOMM)Hmgu
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5548687
Summary 3 genotypes


Genotype
MGI:6360703
hm1
Allelic
Composition
Odad3tm1b(EUCOMM)Hmgu/Odad3tm1b(EUCOMM)Hmgu
Genetic
Background
C57BL/6N-Odad3tm1b(EUCOMM)Hmgu/Cnrm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odad3tm1b(EUCOMM)Hmgu mutation (2 available); any Odad3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between the second postnatal week and the post-weaning period

reproductive system
• in surviving male mice

nervous system
• within the cortex
• severe that is not associated with a discontinuous cerebral aqueduct of Sylvius
• the dorsal part of the lateral ventricle lacks the ependyma cell layer, the loss occurs prior to enlargment
• cerebellar compression
• however, cerebellar volumes are normal

growth/size/body
• at P6 and more so at P10
• in most mice
• in most mice
• in some mice

hematopoietic system
• split at the distal end in some mice
• polycystic in some mice
• in some mice
• in some mice with normal situs

cardiovascular system
• within the cortex

cellular
• in surviving male mice

craniofacial

liver/biliary system
• inverted in some mice

skeleton

immune system
• split at the distal end in some mice
• polycystic in some mice
• in some mice
• in some mice with normal situs

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary ciliary dyskinesia 30 DOID:0110624 OMIM:616037
J:278798




Genotype
MGI:7267054
hm2
Allelic
Composition
Odad3tm1b(EUCOMM)Hmgu/Odad3tm1b(EUCOMM)Hmgu
Genetic
Background
C57BL/6N-Odad3tm1b(EUCOMM)Hmgu/Ieg
Cell Lines HEPD0634_2_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odad3tm1b(EUCOMM)Hmgu mutation (2 available); any Odad3 mutation (27 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6262043
ht3
Allelic
Composition
Odad3tm1b(EUCOMM)Hmgu/Odad3+
Genetic
Background
C57BL/6N-Odad3tm1b(EUCOMM)Hmgu/Ieg
Cell Lines HEPD0634_2_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Odad3tm1b(EUCOMM)Hmgu mutation (2 available); any Odad3 mutation (27 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

skeleton





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory