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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nkg7tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5548721
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nkg7tm1.1(KOMP)Vlcg/Nkg7tm1.1(KOMP)Vlcg C57BL/6N-Nkg7tm1.1(KOMP)Vlcg/Ucd MGI:6263021
hm2
Nkg7tm1.1(KOMP)Vlcg/Nkg7tm1.1(KOMP)Vlcg involves: C57BL/6NTac MGI:6508571


Genotype
MGI:6263021
hm1
Allelic
Composition
Nkg7tm1.1(KOMP)Vlcg/Nkg7tm1.1(KOMP)Vlcg
Genetic
Background
C57BL/6N-Nkg7tm1.1(KOMP)Vlcg/Ucd
Cell Lines 11445A-D4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkg7tm1.1(KOMP)Vlcg mutation (1 available); any Nkg7 mutation (14 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:6508571
hm2
Allelic
Composition
Nkg7tm1.1(KOMP)Vlcg/Nkg7tm1.1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkg7tm1.1(KOMP)Vlcg mutation (1 available); any Nkg7 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced recruitment of MNCs into liver and limited expansion in spleen 14 days after infection with Leishmania donovani
• reduced recruitment of CD4+ T cells into liver 14 days after infection with Leishmania donovani
• reduced levels of CD4+ CD11a+ CD49d+ T cells in liver 14 days after infection with L. donovani
• normal CD4+ T cell levels in spleen 14 days after infection with L. donovani
• decreased T helper 1 cell number
• reduced number in brain after infection with Plasmodium berghei ANKA
• 14 days after infection with Leishmania donovani
• 14 days after infection with Leishmania donovani
• no development of severe neurological sequelae and longer survival till up to 13-14 days post-infection with Plasmodium berghei ANKA
• significantly reduced whole body and brain parasite burden
• reduced capacity to control parasite growth in liver and spleen after infection with L donovani
• failure to clear liver infection 56 days after infection with Leishmania donovani

homeostasis/metabolism
• 14 days after infection with Leishmania donovani
• 14 days after infection with Leishmania donovani

mortality/aging
• no development of severe neurological sequelae and longer survival till up to 13-14 days post-infection with Plasmodium berghei ANKA
• significantly reduced whole body and brain parasite burden
• reduced capacity to control parasite growth in liver and spleen after infection with L donovani
• failure to clear liver infection 56 days after infection with Leishmania donovani

hematopoietic system
N
• no significant hematological changes after infection with Leishmania donovani
• reduced recruitment of MNCs into liver and limited expansion in spleen 14 days after infection with Leishmania donovani
• reduced recruitment of CD4+ T cells into liver 14 days after infection with Leishmania donovani
• reduced levels of CD4+ CD11a+ CD49d+ T cells in liver 14 days after infection with L. donovani
• normal CD4+ T cell levels in spleen 14 days after infection with L. donovani
• decreased T helper 1 cell number
• reduced number in brain after infection with Plasmodium berghei ANKA





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory