Allele Symbol Allele Name Allele ID |
Cdk5rap3tm1b(EUCOMM)Hmgu targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH MGI:5548726 |
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Summary |
3 genotypes
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Data Sources
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice die from E16.5 onward with none present at E18.5
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• impaired differentiation
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• at E16.5, fetal livers exhibit undifferentiated hepatocytes that lack polarity unlike in wild-type livers
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• in the fetus
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• at E16.5
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• increased apoptosis at E14.5 in cells
• however, hepatocytes exhibit normal survival
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• impaired in fetuses
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• at E16.5 in the peripheral blood
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• at E14.5 in fetal livers
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• at E14.5
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• at E14.5 onward
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• impaired differentiation
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Data Sources
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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IMPC - HMGU
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/15/2024 MGI 6.24 |
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