Phenotypes associated with this allele

• Allele Symbol: Sirt1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548731
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt1^tm1b(EUCOMM)Wtsi/Sirt1^tm1b(EUCOMM)Wtsi	C57BL/6N-Sirt1^tm1b(EUCOMM)Wtsi/H	MGI:5757709
ht2	Sirt1^tm1b(EUCOMM)Wtsi/Sirt1^+	C57BL/6N-Sirt1^tm1b(EUCOMM)Wtsi/H	MGI:5757708

Genotype
MGI:5757709

hm1

• Allelic Composition: Sirt1^{tm1b(EUCOMM)Wtsi}/Sirt1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Sirt1^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0428_2_B04

Data Sources

IMPC Data for Sirt1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

♂

IMPC - HAR

abnormal snout morphology ( J:211773 )

♂

IMPC - HAR

growth/size/body

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

abnormal snout morphology ( J:211773 )

♂

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

skeleton

abnormal tooth morphology ( J:211773 )

♂

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

♂

IMPC - HAR

vision/eye

abnormal iris morphology ( J:211773 )

♂

IMPC - HAR

narrow eye opening ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:5757708

ht2

• Allelic Composition: Sirt1^{tm1b(EUCOMM)Wtsi}/Sirt1⁺
• Genetic Background: C57BL/6N-Sirt1^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0428_2_B04

Data Sources

IMPC Data for Sirt1

cardiovascular system

abnormal sinus arrhythmia ( J:211773 )

♀

IMPC - HAR

hematopoietic system

increased basophil cell number ( J:211773 )

IMPC - HAR

immune system

increased basophil cell number ( J:211773 )

IMPC - HAR

skeleton

abnormal scapula morphology ( J:211773 )

IMPC - HAR

abnormal pelvic girdle bone morphology ( J:211773 )

IMPC - HAR