Phenotypes associated with this allele

• Allele Symbol: Clstn3^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548773
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clstn3^tm1b(EUCOMM)Hmgu/Clstn3^tm1b(EUCOMM)Hmgu	C57BL/6N-Clstn3^tm1b(EUCOMM)Hmgu/Cnrm	MGI:5756884
hm2	Clstn3^tm1b(EUCOMM)Hmgu/Clstn3^tm1b(EUCOMM)Hmgu	involves: BALB/cJ * C57BL/6N	MGI:6454068

Genotype
MGI:5756884

hm1

• Allelic Composition: Clstn3^{tm1b(EUCOMM)Hmgu}/Clstn3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Clstn3^{tm1b(EUCOMM)Hmgu}/Cnrm
• Cell Lines: HEPD0538_2_C09

Data Sources

IMPC Data for Clstn3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:211773 )

♂

IMPC - HAR

abnormal gait ( J:211773 )

♂

IMPC - HAR

growth/size/body

increased kidney weight ( J:211773 )

♀

IMPC - HAR

renal/urinary system

increased kidney weight ( J:211773 )

♀

IMPC - HAR

respiratory system

abnormal lung morphology ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:6454068

hm2

• Allelic Composition: Clstn3^{tm1b(EUCOMM)Hmgu}/Clstn3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: BALB/cJ * C57BL/6N

adipose tissue

decreased brown adipose tissue amount ( J:293885 )

• reduced supraclavicular BAT age 17 weeks on normal chow

decreased white adipose tissue amount ( J:293885 )

• reduced epididymal WAT at age 17 weeks on normal chow

decreased bone marrow adipose tissue amount ( J:293885 )

• reduced bone marrow volume

decreased brown fat cell size ( J:293885 )

• in supraclavicular BAT age 17 weeks on normal chow

decreased white fat cell size ( J:293885 )

• in epididymal WAT at age 17 weeks on normal chow

behavior/neurological

behavior/neurological phenotype ( J:293885 )

N • normal physical activity level

growth/size/body

decreased body mass index ( J:293885 )

• from age 6 weeks on normal chow

decreased susceptibility to diet-induced obesity ( J:293885 )

• reduced weight gain at age 16 weeks when on HFD from age 8 weeks

homeostasis/metabolism

decreased circulating glucose level ( J:293885 )

• at age 16 weeks random fed

increased energy expenditure ( J:293885 )

decreased susceptibility to diet-induced obesity ( J:293885 )

• reduced weight gain at age 16 weeks when on HFD from age 8 weeks

increased carbon dioxide production ( J:293885 )

increased oxygen consumption ( J:293885 )

increased insulin sensitivity ( J:293885 )

• at age 17 weeks

increased response to leptin ( J:293885 )

• increased leptin sensitivity

• trend towards lower serum leptin levels

limbs/digits/tail

limbs/digits/tail phenotype ( J:293885 )

N • normal volume fraction, thickness, number, and separation of trabecular bone in distal metaphysis

short femur ( J:293885 )

skeleton

decreased bone marrow adipose tissue amount ( J:293885 )

• reduced bone marrow volume

short femur ( J:293885 )

decreased compact bone mass ( J:293885 )

• at distal metaphysis and midshaft regions of femur

• normal cortical bone thickness