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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casc3tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5548776
Summary 3 genotypes


Genotype
MGI:5630927
hm1
Allelic
Composition		 Casc3tm1.1(KOMP)Vlcg/Casc3tm1.1(KOMP)Vlcg
Genetic
Background		 C57BL/6N-Casc3tm1.1(KOMP)Vlcg/MbpMmucd
Cell Lines 11788B-H10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3tm1.1(KOMP)Vlcg mutation (1 available); any Casc3 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Casc3tm1.1(KOMP)Vlcg/Casc3tm1.1(KOMP)Vlcg mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and although a primitive streak has formed, no other hallmarks typical of gastrulation are seen.

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present at E7.5 (11% versus expected 25%, n=44); no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:279207 )
• although the primitive streak has formed, no other hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos appear smaller than controls at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no morphological embryonic node is present at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos appear smaller than controls at E7.5




Genotype
MGI:7751921
hm2
Allelic
Composition		 Casc3tm1.1(KOMP)Vlcg/Casc3tm1.1(KOMP)Vlcg
Genetic
Background		 C57BL/6NCrl-Casc3tm1.1(KOMP)Vlcg/MbpMmucd
Cell Lines 11788B-H10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3tm1.1(KOMP)Vlcg mutation (1 available); any Casc3 mutation (41 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7751920
ht3
Allelic
Composition		 Casc3tm1.1(KOMP)Vlcg/Casc3+
Genetic
Background		 C57BL/6NCrl-Casc3tm1.1(KOMP)Vlcg/MbpMmucd
Cell Lines 11788B-H10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3tm1.1(KOMP)Vlcg mutation (1 available); any Casc3 mutation (41 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory