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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kctd15tm1b(EUCOMM)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5548790
Summary 6 genotypes


Genotype
MGI:5757276
hm1
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic
Background		 C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ics
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5757277
hm2
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic
Background		 C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

growth/size/body
abnormal embryo size ( J:211773 )
IMPC - TCP

mortality/aging




Genotype
MGI:7657849
hm3
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6N
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
overriding aortic valve ( J:344153 )
• at PO, hearts show an overriding aorta
atrioventricular septal defect ( J:344153 )
• at PO, hearts show an atrioventricular septal defect (AVSD)
perimembraneous ventricular septal defect ( J:344153 )
• mice exhibit congenital subaortic perimembranous ventricular septal defects (VSDs), which can be accompanied by an overriding aorta or an atrioventricular septal defect (AVSD)
bicuspid aortic valve ( J:344153 )
• at E17.5 and P0, hearts exhibit bicuspid aortic valves




Genotype
MGI:6461372
ht4
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15+
Genetic
Background		 C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ics
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:5757275
ht5
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15+
Genetic
Background		 C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

homeostasis/metabolism




Genotype
MGI:7657851
ht6
Allelic
Composition		 Kctd15tm1b(EUCOMM)Wtsi/Kctd15+
Genetic
Background		 involves: C57BL/6N
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1b(EUCOMM)Wtsi mutation (1 available); any Kctd15 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:344153 )
• mice do not exhibit any cardiac abnormalities at PO




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory