Phenotypes associated with this allele

• Allele Symbol: Ndufs1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548814
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndufs1^tm1b(EUCOMM)Hmgu/Ndufs1^tm1b(EUCOMM)Hmgu	C57BL/6N-Ndufs1^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757409
ht2	Ndufs1^tm1b(EUCOMM)Hmgu/Ndufs1^+	C57BL/6N-Ndufs1^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757408

Genotype
MGI:5757409

hm1

• Allelic Composition: Ndufs1^{tm1b(EUCOMM)Hmgu}/Ndufs1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ndufs1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0685_5_C11

Data Sources

IMPC Data for Ndufs1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757408

ht2

• Allelic Composition: Ndufs1^{tm1b(EUCOMM)Hmgu}/Ndufs1⁺
• Genetic Background: C57BL/6N-Ndufs1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0685_5_C11

Data Sources

IMPC Data for Ndufs1

behavior/neurological

decreased vertical activity ( J:211773 )

♂

IMPC - HMGU

decreased locomotor activity ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - HMGU

decreased circulating triglyceride level ( J:211773 )

♂

IMPC - HMGU

increased circulating calcium level ( J:211773 )

IMPC - HMGU

increased circulating phosphate level ( J:211773 )

IMPC - HMGU

increased circulating sodium level ( J:211773 )

IMPC - HMGU

increased circulating lipase level ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

♂

IMPC - HMGU

decreased total retina thickness ( J:211773 )

IMPC - HMGU

abnormal vitreous body morphology ( J:211773 )

IMPC - HMGU