Analysis Tools
hearing/vestibular/ear
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• stereocilia reduced to one row and several hair cells are missing at P11
• loss of the third row of stereocilia prior the onset of hearing at P245
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• at P245
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• a few missing stereocilia in the shorter third row of outer hair cell cilia at P11, which are almost completely lost by P49
• at P245
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• highly reduced maximal current at P11, but not P8-P9, when the membrane is depolarized to +96 mV
• reduced current at P11
• however, mice exhibit normal resting current at positive and negative membrane potentials and basolateral membrane property development
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• reduced for clicks at 2 months to levels observed in P14 mice
• absent for clicks at 5-8 months of age
• reduced pure-tone evoked ABRs
• increased wave 1 amplitude that parallels the increase in ABR threshold suggesting loss of cochlear compression with increasing stimulus levels
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• increased threshold for distortion product otoacoustic emissions (DOPAE)
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• early and progressive
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nervous system
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• at P245
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• a few missing stereocilia in the shorter third row of outer hair cell cilia at P11, which are almost completely lost by P49
• at P245
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• highly reduced maximal current at P11, but not P8-P9, when the membrane is depolarized to +96 mV
• reduced current at P11
• however, mice exhibit normal resting current at positive and negative membrane potentials and basolateral membrane property development
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