Phenotypes associated with this allele

• Allele Symbol: Scarb1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548930
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scarb1^tm1b(EUCOMM)Wtsi/Scarb1^tm1b(EUCOMM)Wtsi	C57BL/6N-Scarb1^tm1b(EUCOMM)Wtsi/Bay	MGI:5757679
ht2	Scarb1^tm1b(EUCOMM)Wtsi/Scarb1^+	C57BL/6N-Scarb1^tm1b(EUCOMM)Wtsi/Bay	MGI:5757678

Genotype
MGI:5757679

hm1

• Allelic Composition: Scarb1^{tm1b(EUCOMM)Wtsi}/Scarb1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Scarb1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0548_1_A10

Data Sources

IMPC Data for Scarb1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased vertical activity ( J:211773 )

♂

IMPC - BCM

cardiovascular system

enlarged heart ( J:211773 )

♂

IMPC - BCM

increased heart weight ( J:211773 )

♂

IMPC - BCM

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - BCM

increased heart weight ( J:211773 )

♂

IMPC - BCM

enlarged spleen ( J:211773 )

♂

IMPC - BCM

increased spleen weight ( J:211773 )

♂

IMPC - BCM

hematopoietic system

enlarged spleen ( J:211773 )

♂

IMPC - BCM

increased spleen weight ( J:211773 )

♂

IMPC - BCM

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - BCM

immune system

enlarged spleen ( J:211773 )

♂

IMPC - BCM

increased spleen weight ( J:211773 )

♂

IMPC - BCM

Genotype
MGI:5757678

ht2

• Allelic Composition: Scarb1^{tm1b(EUCOMM)Wtsi}/Scarb1⁺
• Genetic Background: C57BL/6N-Scarb1^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0548_1_A10

Data Sources

IMPC Data for Scarb1

cardiovascular system

cardiovascular system phenotype ( J:211773 )

IMPC - BCM

abnormal sinus arrhythmia ( J:211773 )

♀

IMPC - BCM

decreased heart rate ( J:211773 )

IMPC - BCM

prolonged RR interval ( J:211773 )

♂

IMPC - BCM

prolonged PQ interval ( J:211773 )

IMPC - BCM

prolonged ST segment ( J:211773 )

♂

IMPC - BCM