Phenotypes associated with this allele

• Allele Symbol: Pcsk1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548957
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcsk1^tm1b(EUCOMM)Wtsi/Pcsk1^tm1b(EUCOMM)Wtsi	C57BL/6N-Pcsk1^tm1b(EUCOMM)Wtsi/Ics	MGI:5757489
ht2	Pcsk1^tm1b(EUCOMM)Wtsi/Pcsk1^+	C57BL/6N-Pcsk1^tm1b(EUCOMM)Wtsi/Ics	MGI:5757488

Genotype
MGI:5757489

hm1

• Allelic Composition: Pcsk1^{tm1b(EUCOMM)Wtsi}/Pcsk1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pcsk1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0508_1_C08

Data Sources

IMPC Data for Pcsk1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757488

ht2

• Allelic Composition: Pcsk1^{tm1b(EUCOMM)Wtsi}/Pcsk1⁺
• Genetic Background: C57BL/6N-Pcsk1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0508_1_C08

Data Sources

IMPC Data for Pcsk1

behavior/neurological

abnormal freezing behavior ( J:211773 )

♀

IMPC - ICS

decreased locomotor activity ( J:211773 )

♀

IMPC - ICS

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - ICS

abnormal vitreous body morphology ( J:211773 )

♂

IMPC - ICS

persistence of hyaloid vascular system ( J:211773 )

♂

IMPC - ICS