Phenotypes associated with this allele

• Allele Symbol: Alkbh4^tm1Geno
• Allele Name: targeted mutation 1, Genoway
• Allele ID: MGI:5549954
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alkbh4^tm1Geno/Alkbh4^tm1Geno Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5549958

Genotype
MGI:5549958

cn1

• Allelic Composition: Alkbh4^tm1Geno/Alkbh4^tm1Geno; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal centrosome morphology ( J:205739 )

• increased centrosome number is likely a consequence of polyploidy caused by cells failing to go through cytokinesis

increased cell nucleus count ( J:205739 )

• increased frequency of multinucleation in tamoxifen-treated mouse embryonic fibroblasts due to aborted cytokinesis

abnormal mitotic cytokinesis ( J:205739 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit defects in the organization of the cleavage furrow, increased frequency of multinucleation due to aborted cytokinesis and increased centrosomes number likely a consequence of polyploidy compared with control cells

• however, complementation with the wild-type protein rescues cytokinesis defects

decreased fibroblast cell migration ( J:205739 )

• in tamoxifen-treated mouse embryonic fibroblasts