mortality/aging
N |
• mice are viable
|
reproductive system
• in the cauda epididymis
|
• however, flagella contain 9+2 axoneme organization
|
• cytoplasmic droplets attached to the annulus of the tail
|
• increased apoptosis during spermatogenesis and in the seminiferous tubules
|
• from male mice
|
• male mice produce smaller than expected litters
|
behavior/neurological
N |
• mice exhibit normal working memory, muscle strength, motor coordination, balance and thermal nociception
|
• mice spend slightly more time in the border area of an open field
• however, mice exhibit normal behavior in an elevated plus maze
|
cellular
• lack of K40 alpha-tubulin acetylation in the majority of tissues tested
• however, ciliated organelles are morphologically normal
|
• in the cauda epididymis
|
• however, flagella contain 9+2 axoneme organization
|
• cytoplasmic droplets attached to the annulus of the tail
|
• increased apoptosis during spermatogenesis and in the seminiferous tubules
|
hematopoietic system
N |
• mice exhibit normal peripheral blood parameters
|
integument
N |
• mice exhibit normal thermal nociception
|
endocrine/exocrine glands