Analysis Tools
growth/size/body
| N |
• after 5 days of tamoxifen treatment, mice display no weight loss and appeared healthy at 2 and 4 weeks post-tamoxifen; no overt phenotype is observed 3 months following 2 months of tamoxifen treatment
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immune system
| N |
• no cellular infiltrates (suggesting autoimmune responses) are detected in organs including liver, kidney, pancreas, heart, colon and thyroid gland from animals that received tamoxifen treatment
• no secondary effects on B cell tolerance indicated by autoantibody production are seen in mice at 6 weeks or 5 months after tamoxifen treatment
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• at 2 and 4 weeks after tamoxifen treatment, mice show a modest but significant transient expansion of effector memory T cells in the spleen and lymph nodes; numbers and frequency of effector memory cells return to control levels at 6 weeks after tamoxifen administration as result of replacement with new T cells
• proliferation of effector memory T cells is increased without similar increase observed for naive T cells or central memory CD4+ T cells
• in mice thymectomized prior to tamoxifen treatment, elevation of effector memory T cells persists in absence of thymic emigration
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• hyperproliferation of regulatory T cells is observed at 2 an 4 weeks after tamoxifen treatment; increased numbers are observed in lymph nodes, the spleen, the lung and Peyer's patches, but not in intestinal lamina propria
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hematopoietic system
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• at 2 and 4 weeks after tamoxifen treatment, mice show a modest but significant transient expansion of effector memory T cells in the spleen and lymph nodes; numbers and frequency of effector memory cells return to control levels at 6 weeks after tamoxifen administration as result of replacement with new T cells
• proliferation of effector memory T cells is increased without similar increase observed for naive T cells or central memory CD4+ T cells
• in mice thymectomized prior to tamoxifen treatment, elevation of effector memory T cells persists in absence of thymic emigration
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• hyperproliferation of regulatory T cells is observed at 2 an 4 weeks after tamoxifen treatment; increased numbers are observed in lymph nodes, the spleen, the lung and Peyer's patches, but not in intestinal lamina propria
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