Phenotypes associated with this allele

• Allele Symbol: Rarres2^tm1Yktk
• Allele Name: targeted mutation 1, Yutaka Takahashi
• Allele ID: MGI:5550146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rarres2^tm1Yktk/Rarres2^tm1Yktk	B6.Cg-Rarres2^tm1Yktk	MGI:5550223

Genotype
MGI:5550223

hm1

• Allelic Composition: Rarres2^tm1Yktk/Rarres2^tm1Yktk
• Genetic Background: B6.Cg-Rarres2^tm1Yktk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:206120 )

N • mice exhibit normal insulin sensitivity

decreased insulin secretion ( J:206120 )

• impaired glucose- or KCl-stimulated insulin secretion

• however, islet insulin levels are normal

increased circulating glucose level ( J:206120 )

• in a glucose tolerance test

decreased circulating free fatty acids level ( J:206120 )

abnormal gluconeogenesis ( J:206120 )

• increased clamp hepatic glucose production

• however, basal production is normal

impaired glucose tolerance ( J:206120 )

• whether mice are fed standard chow or a high fat diet

endocrine/exocrine glands

decreased insulin secretion ( J:206120 )

• impaired glucose- or KCl-stimulated insulin secretion

• however, islet insulin levels are normal

immune system

decreased macrophage cell number ( J:206120 )

• in adipose tissue

muscle

increased muscle cell glucose uptake ( J:206120 )

• enhanced as indicated by increased glucose disappearance rate

hematopoietic system

decreased macrophage cell number ( J:206120 )

• in adipose tissue

cellular

increased muscle cell glucose uptake ( J:206120 )

• enhanced as indicated by increased glucose disappearance rate