mortality/aging
• mice die by 2 weeks of age
|
nervous system
• shallower
• abnormal pattern
|
• Purkinje cells fail to form a uniform monolayer
|
• both internal and external layers are thinner with reduced cellularity
|
• virtually absent
|
behavior/neurological
growth/size/body
• appear normal at 1 day after birth
• markedly reduced in size at 10 days of age
|
skeleton
• reduced in size
|
pigmentation
cardiovascular system
cellular
• absolute numbers of hematopoietic stem cells are reduced
|
endocrine/exocrine glands
• less cellular, particularly in the cortex
|
small thymus
(
J:201153
)
• reduced in size
|
hematopoietic system
• absolute numbers of hematopoietic stem cells are reduced
|
• less cellular, particularly in the cortex
|
small thymus
(
J:201153
)
• reduced in size
|
• normal at E18.5 but absent at 10-12 days of age
|
• cellularity begins declining at 1 day of age
• virtually aplastic at 10-12 days of age
|
small spleen
(
J:201153
)
• reduced spleen size and cellularity
• sparse extramedulary hematopoiesis
|
• less cellularity
|
immune system
• less cellular, particularly in the cortex
|
small thymus
(
J:201153
)
• reduced in size
|
small spleen
(
J:201153
)
• reduced spleen size and cellularity
• sparse extramedulary hematopoiesis
|
• less cellularity
|
• gut associated lymphoid tissue is not apparent or shows very reduced cellularity
|
integument
limbs/digits/tail
• reduced in size
|
• abnormal tail tip
|
kinked tail
(
J:201153
)