Phenotypes associated with this allele

• Allele Symbol: Igk-J^{tm2.1(4E10)Lave}
• Allele Name: targeted mutation 2.1, Laurent Verkoczy
• Allele ID: MGI:5550248
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm2.1(4E10)Lave/Igh-J^tm2.1(4E10)Lave Igk-J^tm2.1(4E10)Lave/Igk-J^tm2.1(4E10)Lave	involves: C57BL/6	MGI:5550252

Genotype
MGI:5550252

cx1

• Allelic Composition: Igh-J^{tm2.1(4E10)Lave}/Igh-J^{tm2.1(4E10)Lave}; Igk-J^{tm2.1(4E10)Lave}/Igk-J^{tm2.1(4E10)Lave}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:205708 )

• modest blockage at the pro/large pre-B to small pre-B transition

decreased immature B cell number ( J:205708 )

arrested B cell differentiation ( J:205708 )

• B cell development is blocked at the small pre-B to immature B transition

decreased mature B cell number ( J:205708 )

abnormal B cell physiology ( J:205708 )

• B cells exhibit elevated basal activation and muted response to BCR ligation

hematopoietic system

abnormal B cell differentiation ( J:205708 )

• modest blockage at the pro/large pre-B to small pre-B transition

decreased immature B cell number ( J:205708 )

arrested B cell differentiation ( J:205708 )

• B cell development is blocked at the small pre-B to immature B transition

decreased mature B cell number ( J:205708 )

abnormal B cell physiology ( J:205708 )

• B cells exhibit elevated basal activation and muted response to BCR ligation