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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnf31tm1.1Kiwa
targeted mutation 1.1, Kazuhiro Iwai
MGI:5550368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj MGI:5550380


Genotype
MGI:5550380
cn1
Allelic
Composition		 Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Rnf31tm1.1Kiwa mutation (3 available); any Rnf31 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:201885 )
N
• mice exhibit normal conventional B cell development and I cell populations
abnormal B-1 B cell morphology ( J:201885 )
• severely impaired B1 B cell development in the peritoneal cavity
decreased B-1a cell number ( J:201885 )
• in the peritoneal cavity
decreased B-1b cell number ( J:201885 )
• in the peritoneal cavity
abnormal humoral immune response ( J:201885 )
• impaired antibody responses to both T cell-dependent and T cell-independent type 2 antigens
decreased IgA level ( J:201885 )
• in unimmunized mice
decreased IgG1 level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-CGG
decreased IgG2a level ( J:201885 )
• in unimmunized mice
decreased IgG2b level ( J:201885 )
• in unimmunized mice
decreased IgG3 level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-Ficoll
decreased IgM level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-CGG or NP-Ficoll

hematopoietic system
abnormal B-1 B cell morphology ( J:201885 )
• severely impaired B1 B cell development in the peritoneal cavity
decreased B-1a cell number ( J:201885 )
• in the peritoneal cavity
decreased B-1b cell number ( J:201885 )
• in the peritoneal cavity
decreased IgA level ( J:201885 )
• in unimmunized mice
decreased IgG1 level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-CGG
decreased IgG2a level ( J:201885 )
• in unimmunized mice
decreased IgG2b level ( J:201885 )
• in unimmunized mice
decreased IgG3 level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-Ficoll
decreased IgM level ( J:201885 )
• in unimmunized mice
• in mice immunized with NP-CGG or NP-Ficoll




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory