All Phenotypes Tg(Ucp1-cre)1Evdr MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Ucp1-cre)1Evdr
transgene insertion 1, Evan Rosen
MGI:5550468

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm3(Irf4)Evdr}/Gt(ROSA)26Sor⁺ Tg(Ucp1-cre)1Evdr/0	involves: 129 * C57BL/6J * FVB	MGI:6112616
cn2	Irf4^tm1Rdf/Irf4^tm1Rdf Tg(Ucp1-cre)1Evdr/0	involves: 129S1/Sv * C57BL/6J * FVB	MGI:6112615
cn3	Pparg^tm2Rev/Pparg^tm2Rev Tg(Ucp1-cre)1Evdr/0	involves: 129S4/SvJae * FVB	MGI:6361694
cn4	Tg(Ucp1-cre)1Evdr/0 Zc3h10^{tm1c(EUCOMM)Wtsi}/Zc3h10^{tm1c(EUCOMM)Wtsi}	involves: 129S4/SvJaeSor * C57BL/6N * FVB	MGI:6415592
cn5	Slc25a44^em1Kajim/Slc25a44^em1Kajim Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6 * FVB	MGI:7596327
cn6	Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6J * C57BL/6N * FVB	MGI:7610686
cn7	Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi} Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6N * FVB	MGI:6457283
cn8	Bckdha^{tm1a(EUCOMM)Hmgu}/Bckdha^{tm1a(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6N * FVB	MGI:6361695
cn9	Pex16^{tm1c(EUCOMM)Hmgu}/Pex16^{tm1c(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6N * FVB * SJL	MGI:6682103

Allelic Composition	Gt(ROSA)26Sor^{tm3(Irf4)Evdr}/Gt(ROSA)26Sor⁺ Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: 129 * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(Irf4)Evdr} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal adipose tissue development ( J:214637 )

• reduced lipogenesis in brown adipocytes

decreased body fat mass ( J:214637 )

• on standard chow and a high-fat diet

abnormal white fat cell size ( J:214637 )

• less hypertrophy when fed a high-fat diet than in control mice

decreased epididymal fat pad weight ( J:214637 )

• on a high-fat diet

decreased inguinal fat pad weight ( J:214637 )

• on a high-fat diet

browned white adipose tissue morphology ( J:214637 )

homeostasis/metabolism

increased energy expenditure ( J:214637 )

• on a high-fat diet

increased carbon dioxide production ( J:214637 )

• on a high-fat diet

increased oxygen consumption ( J:214637 )

• on a high-fat diet

improved glucose tolerance ( J:214637 )

• on a high-fat diet

increased insulin sensitivity ( J:214637 )

• on a high-fat diet

growth/size/body

decreased body fat mass ( J:214637 )

• on standard chow and a high-fat diet

decreased body weight ( J:214637 )

• on standard chow and a high-fat diet

behavior/neurological

behavior/neurological phenotype ( J:214637 )

N	• mice exhibit normal food intake and physical activity when fed standard chow or a high-fat diet

cellular

abnormal cellular respiration ( J:214637 )

• increased uncoupled respiration in brown adipose tissue mitochondria

Allelic Composition	Irf4^tm1Rdf/Irf4^tm1Rdf Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4^tm1Rdf mutation (1 available); any Irf4 mutation (28 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal adipose tissue development ( J:214637 )

• reduced lipogenesis in isopropetenol-treated adipocytes

increased body fat mass ( J:214637 )

• small increased when fed standard chow

• elevated when fed a high-fat diet

increased white fat cell size ( J:214637 )

• in inguinal and epididymal fat pads with increased lipid content

increased epididymal fat pad weight ( J:214637 )

increased inguinal fat pad weight ( J:214637 )

homeostasis/metabolism

decreased fatty acid oxidation ( J:214637 )

impaired adaptive thermogenesis ( J:214637 )

• in cold-exposed mice

decreased core body temperature ( J:214637 )

• in cold-exposed mice

decreased carbon dioxide production ( J:214637 )

decreased oxygen consumption ( J:214637 )

impaired glucose tolerance ( J:214637 )

• when fed a high-fat diet

insulin resistance ( J:214637 )

• when fed a high-fat diet

impaired lipolysis ( J:214637 )

• when mice are fed standard chow

growth/size/body

increased body fat mass ( J:214637 )

• small increased when fed standard chow

• elevated when fed a high-fat diet

increased body weight ( J:214637 )

• when fed a high-fat diet despite normal food intake

cellular

abnormal cellular respiration ( J:214637 )

• reduced in the mitochondria of brown adipocytes despite normal mitochondrial number and cristae density

decreased fatty acid oxidation ( J:214637 )

Allelic Composition	Pparg^tm2Rev/Pparg^tm2Rev Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pparg^tm2Rev mutation (1 available); any Pparg mutation (41 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal interscapular fat pad morphology ( J:278806 )

• composed of unilocular adipocytes and fibrotic tissues unlike in controls

homeostasis/metabolism

abnormal amino acid metabolism ( J:278806 )

• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice

Allelic Composition	Tg(Ucp1-cre)1Evdr/0 Zc3h10^{tm1c(EUCOMM)Wtsi}/Zc3h10^{tm1c(EUCOMM)Wtsi}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ucp1-cre)1Evdr mutation (1 available)
Zc3h10^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Zc3h10 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:287066 )

• in males on a normal chow diet

abnormal brown adipose tissue thermogenesis ( J:287066 )

• 30% decrease in oxygen consumption in brown adipose tissue from males

• temperature of brown fat in cold exposed males is markedly decreased compared to wild-type controls

growth/size/body

increased body fat mass ( J:287066 )

• in males on a normal chow diet

increased body weight ( J:287066 )

• in males on a normal chow diet

homeostasis/metabolism

impaired adaptive thermogenesis ( J:287066 )

• greater drop in body temperature in males after 3h of cold exposure compared to wild-type controls

decreased oxygen consumption ( J:287066 )

• at all temperatures without changes in food consumption or physical activity in males

impaired glucose tolerance ( J:287066 )

• higher glucose levels in a glucose tolerance test in males

insulin resistance ( J:287066 )

• impaired insulin sensitivity in males during an insulin tolerance test

Allelic Composition	Slc25a44^em1Kajim/Slc25a44^em1Kajim Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a44^em1Kajim mutation (0 available); any Slc25a44 mutation (10 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal brown adipose tissue physiology ( J:345254 )

• mitochondrial valine oxidation is reduced by 70% in brown adipose tissue (BAT) indicating reduced branched amino acid oxidation

homeostasis/metabolism

impaired febrile response ( J:345254 )

• prostaglandin E2 (PGE2)-induced febrile response is substantially attenuated relative to controls, with lower total heat production and lower maximum temperature

• however, no difference in the velocity of the initial rise in iBAT temperature for the first 5 min after PGE2 administration is seen

growth/size/body

growth/size/body region phenotype ( J:345254 )

N	• mice exhibit normal body weight and tissue mass of metabolic organs, including brown adipose tissue, liver, white adipose tissue, and skeletal muscle on a regular chow diet and no differences in brown adipocytes are seen

Allelic Composition	Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: C57BL/6J * C57BL/6N * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpcpd1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Gpcpd1 mutation (32 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

• do not show glucose intolerance at 12 weeks of age

Allelic Composition	Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi} Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: C57BL/6N * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2c(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (25 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

adipose tissue phenotype ( J:287419 )

N	• mice exhibit normal adaptive thermogenesis under any lighting condition

Allelic Composition	Bckdha^{tm1a(EUCOMM)Hmgu}/Bckdha^{tm1a(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: C57BL/6N * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bckdha^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Bckdha mutation (35 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased fatty acid oxidation ( J:278806 )

• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures

impaired adaptive thermogenesis ( J:278806 )

• in brown adipose tissue following treatment with noradrenaline

• however, muscle response is normal

decreased core body temperature ( J:278806 )

• after cold exposure without affecting muscle shivering

impaired febrile response ( J:345254 )

• prostaglandin E2 (PGE2)-induced febrile response is substantially attenuated relative to controls, with lower total heat production and lower maximum temperature

• however, no difference is seen in the velocity of the initial brown adipose tissue temperature change

impaired glucose tolerance ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

insulin resistance ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

increased liver triglyceride level ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

abnormal amino acid metabolism ( J:278806 )

• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice

adipose tissue

increased total body fat amount ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

abnormal brown adipose tissue physiology ( J:278806 )

• reduced glucose and fatty acid oxidation in brown adipose tissue of mice fed a high-fat diet at ambient temperatures

growth/size/body

increased body weight ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures despite normal lean mass

increased liver weight ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

liver/biliary system

increased liver weight ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

increased liver triglyceride level ( J:278806 )

• in mice fed a high-fat diet at ambient temperatures

behavior/neurological

behavior/neurological phenotype ( J:278806 )

N	• at ambient temperatures, mice fed a high-fat diet exhibit normal food intake

cellular

decreased fatty acid oxidation ( J:278806 )

• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures

Allelic Composition	Pex16^{tm1c(EUCOMM)Hmgu}/Pex16^{tm1c(EUCOMM)Hmgu} Tg(Ucp1-cre)1Evdr/0
Genetic Background	involves: C57BL/6N * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pex16^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Pex16 mutation (23 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:270463 )

• modest

decreased oxygen consumption ( J:270463 )

• reduced oxygen consumption after treatment with norepinephrine

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