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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxf1tm2Rhc
targeted mutation 2, Robert H Costa
MGI:5550485
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550501
cn2
 		Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550502


Genotype
MGI:5550501
cn1
Allelic
Composition		 Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (13 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:203847 )
• mice die prior to or immediately after birth

digestive/alimentary system
dilated esophagus ( J:203847 )
• distended esophagus

muscle




Genotype
MGI:5550502
cn2
Allelic
Composition		 Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (13 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:203847 )
• no time point given

muscle
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon
impaired contractility of intestinal smooth muscle ( J:203847 )
• impaired depolarization induced contractility of colonic rings

digestive/alimentary system
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory