Phenotypes associated with this allele

• Allele Symbol: Mapt^{tm1(Sema3e)Yuyo}
• Allele Name: targeted mutation 1, Yutaka Yoshida
• Allele ID: MGI:5550516
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mapt^tm1(Sema3e)Yuyo/Mapt^+ Olig2^tm1(cre)Tmj/Olig2^+	Not Specified	MGI:5550524

Genotype
MGI:5550524

cn1

• Allelic Composition: Mapt^{tm1(Sema3e)Yuyo}/Mapt⁺; Olig2^tm1(cre)Tmj/Olig2⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:205528 )

N • normal proprioceptive sensory axonal projection to the ventral spinal cord

abnormal sensory neuron innervation pattern ( J:205528 )

• decrease in monosynaptic sensory-motor connections from sensory neurons innervating the hamstring knee flexor muscle

abnormal synaptic bouton morphology ( J:205528 )

• number of boutons on the soma of motor neurons innervating the hamstring knee flexor muscle are reduced while the density of boutons in the vicinity remains normal

• normal vGlut+ boutons on Glu motor neurons

abnormal excitatory postsynaptic potential ( J:205528 )

• mean amplitudes of the monosynaptic EPSPs in motor neurons innervating the hamstring knee flexor muscle are reduced comparing to wild-type