Phenotypes associated with this allele

• Allele Symbol: Il6ra^tm1.2Jcbr
• Allele Name: targeted mutation 1.2, Jens C Bruning
• Allele ID: MGI:5550551
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il6ra^tm1.2Jcbr/Il6ra^tm1.2Jcbr	involves: C57BL/6	MGI:5550555

Genotype
MGI:5550555

hm1

• Allelic Composition: Il6ra^tm1.2Jcbr/Il6ra^tm1.2Jcbr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:188445 )

• some mice infected with a lethal course of P. chabaudi survive unlike control mice

immune system

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

liver inflammation ( J:202764 )

• reduced in mice fed standard chow and treated with DEN

• however, mice fed a high fat diet exhibit normal liver inflammation

decreased susceptibility to parasitic infection ( J:188445 )

• mice infected with P. chabaudi exhibit lower IL1b and TNF-alpha levels and decreased lethality compared with control mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:188445 )

• some mice infected with a lethal course of P. chabaudi survive unlike control mice

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:188445 )

• in mice infected with P. chabaudi

decreased circulating tumor necrosis factor level ( J:188445 )

• in mice infected with P. chabaudi

increased circulating aspartate transaminase level ( J:202764 )

• in mice fed standard chow and treated with DEN

decreased incidence of tumors by chemical induction ( J:202764 )

• mice fed standard chow and treated with DEN develop fewer and smaller hepatocellular carcinoma (HCC) compared with wild-type mice

• however, mice fed a high fat diet and treated with DEN exhibit normal HCC development

liver/biliary system

increased hepatocyte apoptosis ( J:202764 )

• in mice fed standard chow and treated with DEN

• however, mice fed a high fat diet exhibit normal liver apoptosis

decreased hepatocyte proliferation ( J:202764 )

• in mice fed standard chow prior to DEN treatment

• however, proliferation is normal following DEN treatment

liver inflammation ( J:202764 )

• reduced in mice fed standard chow and treated with DEN

• however, mice fed a high fat diet exhibit normal liver inflammation

neoplasm

decreased incidence of tumors by chemical induction ( J:202764 )

• mice fed standard chow and treated with DEN develop fewer and smaller hepatocellular carcinoma (HCC) compared with wild-type mice

• however, mice fed a high fat diet and treated with DEN exhibit normal HCC development

decreased tumor growth/size ( J:202764 )

• mice fed standard chow and treated with DEN develop fewer and smaller hepatocellular carcinoma (HCC) with increased apoptosis compared with wild-type mice

• however, mice fed a high fat diet and treated with DEN exhibit normal HCC development

cellular

increased hepatocyte apoptosis ( J:202764 )

• in mice fed standard chow and treated with DEN

• however, mice fed a high fat diet exhibit normal liver apoptosis

decreased hepatocyte proliferation ( J:202764 )

• in mice fed standard chow prior to DEN treatment

• however, proliferation is normal following DEN treatment

growth/size/body

growth/size/body region phenotype ( J:202764 )

N • mice fed a high fat diet and induced with DEN exhibit normal obesity